Results 271 to 280 of about 116,954 (354)

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges

MedComm, Volume 7, Issue 1, January 2026.
Organoids offer transformative 3D models that precisely mimic human organ architecture and function. This review details the latest methodology, emphasizing the cultivation of liver and other abdominal organoids. We analyze technological challenges (e.g., nutrient delivery, scalability, diversity) and provide practical insights for new researchers ...
Chunbao Jiao, Omer Faruk Karakaya, Neda Dadgar, Chase J. Wehrle, Zahra Massoud, Hanna Hong, Robert L. Fairchild, Nic Leipzig, Federico Aucejo, Wen Wee Ma, Jan Joseph Melenhorst, Sofia Ferreira Gonzales, Andrea Schlegel   +12 more
wiley   +1 more source

SARS-CoV-2 Spike S1 Subunit Triggers Pericyte and Microvascular Dysfunction in Human Pancreatic Islets. [PDF]

Diabetes
Andrade Barboza C, Gonçalves LM, Pereira E, Cruz RD, Andrade Louzada R, Boulina M, Almaça J.   +6 more
europepmc   +1 more source

Intrapancreatic islet transplantation as a potential solution to chronic failure of intraportal islet grafts. [PDF]

, 1993
Carroll, PB, Demetris, AJ, Fontes, PA, Ildstad, ST, Nussler, AK, Ricordi, C, Rilo, HL, Starzl, TE, Tzakis, AG   +8 more
core  

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence. [PDF]

Nat Metab
Carapeto P, Iwasaki K, Hela F, Kahng J, Alves-Wagner AB, Middelbeek RJW, Hirshman MF, Rutter GA, Goodyear LJ, Aguayo-Mazzucato C.   +9 more
europepmc   +1 more source

One Year of Exercise After Weight Loss Increases Postprandial GLP‐1 Secretion in Contrast to Usual Activity or GLP‐1 Receptor Agonist Treatment

Obesity, Volume 34, Issue 1, Page 51-57, January 2026.
ABSTRACT Objective Incretin‐based obesity medication maintains weight loss by mimicking the appetite‐inhibiting hormone GLP‐1. Interestingly, chronic exercise may improve postprandial appetite control by increasing late postprandial secretion of endogenous GLP‐1.
Joachim Holt, Rasmus Michael Sandsdal, Sarah Byberg, Charlotte Janus, Christian Rimer Juhl, Julie Rehné Jørgensen, Bolette Hartmann, Bente Stallknecht, Jens Juul Holst, Sten Madsbad, Simon Birk Kjær Jensen, Signe Sørensen Torekov   +11 more
wiley   +1 more source

Tipping-point transition from transient to persistent inflammation in pancreatic islets. [PDF]

NPJ Syst Biol Appl
Holst-Hansen T, Nielsen PY, Jensen MH, Mandrup-Poulsen T, Trusina A.   +4 more
europepmc   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, Volume 22, Issue 1, 2 January 2026.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

Long-term culture of human pancreatic islets reveals reduced metal ion pathways in their gene signature. [PDF]

Cell Transplant
Kato H, Sigdel TK, Sheta M, Omori K, Qi M, Kandeel F, Komatsu H.   +6 more
europepmc   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, Volume 6, Issue 1, January 2026.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source