Results 281 to 290 of about 116,954 (354)

Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes. [PDF]

BMJ Open Diabetes Res Care
Radenkovic M, Arvastsson J, Sarmiento L, Cilio CM.   +3 more
europepmc   +1 more source

Effects of Short‐Term Intensive Insulin Therapy Combined With Oral Hypoglycemic Agents for Inducing Remission in Newly Diagnosed Type 2 Diabetes Mellitus: A Randomized Clinical Trial

Journal of Diabetes, Volume 18, Issue 1, January 2026.
The addition of insulin sensitizers (metformin and pioglitazone) or sitagliptin to short‐term intensive insulin therapy (SIIT) facilitated SIIT implementation and enhanced short‐term glycemic control in patients with newly diagnosed type 2 diabetes. However, 12‐month remission rates were similar to SIIT alone, suggesting a need for prolonged therapy ...
Weijian Ke, Liehua Liu, Pengyuan Zhang, Li Yan, Qian Zhang, Fan Zhang, Xuejuan Xu, Juan Liu, Lijuan Xu, Xuesi Wan, Hai Li, Xiaopei Cao, Haipeng Xiao, Melissa S. Putman, Yanbing Li   +14 more
wiley   +1 more source

Identification of unique cell type responses in pancreatic islets to stress. [PDF]

Nat Commun
Maestas MM, Ishahak M, Augsornworawat P, Veronese-Paniagua DA, Maxwell KG, Velazco-Cruz L, Marquez E, Sun J, Shunkarova M, Gale SE, Urano F, Millman JR.   +11 more
europepmc   +1 more source

“Adrenergic receptors and monoamines in the brain and pancreatic islets of streptozotoein diabetic rats: Role in insulin secretion as a function of age”

, 2014
Abraham Asha, C.S. Paulose
openalex   +1 more source

Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue mass and downregulates senescence‐associated secreted phenotype‐related genes in the tissue, suggesting that COX7RP plays a role in preventing aging through
Kazuhiro Ikeda, Sachiko Shiba, Masataka Yokoyama, Masanori Fujimoto, Kuniko Horie, Tomoaki Tanaka, Satoshi Inoue   +6 more
wiley   +1 more source

Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes. [PDF]

EMBO J
Qadir MMF, Elgamal RM, Song K, Kudtarkar P, Sakamuri SSVP, Katakam PV, El-Dahr SS, Kolls JK, Gaulton KJ, Mauvais-Jarvis F.   +9 more
europepmc   +1 more source

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao, Zicheng Zhang, Tong Li, Yuyin Jiang, Yuanxin Liu, Tingting Lv, Lianju Qin, Yunxia Zhu, Wei Tang   +8 more
wiley   +1 more source

High-Efficiency, Prevascularization-Free Macroencapsulation System for Subcutaneous Transplantation of Pancreatic Islets for Enhanced Diabetes Treatment. [PDF]

Adv Mater
Jeon S, Heo JH, Myung N, Shin JY, Kim MK, Kang HW.   +5 more
europepmc   +1 more source

Uncoupling Insulin Sensitivity From Longevity: A Sex‐Dependent Effect of Hepatic Glucagon Signaling

Aging Cell, Volume 25, Issue 1, January 2026.
Hepatic glucagon receptor knockout enhances metabolic health but shortens lifespan in female mice due to late‐life inflammation via NF‐κB and cGAS‐STING pathways, revealing a sexually dimorphic role in longevity despite metabolic benefits. ABSTRACT Glucagon, a key hormone in maintaining euglycemia during fasting, also exerts broad metabolic effects ...
Alexander Tate Lasher, Ben Heckman, Parth Sarker, Kaimao Liu, Liou Y. Sun   +4 more
wiley   +1 more source

Hydrogen sulfide: an emerging gasotransmitter involved in the survival of pancreatic islets during diabetes therapy. [PDF]

Med Gas Res
Karunakaran U.
europepmc   +1 more source