Results 21 to 30 of about 53,803 (167)

GABA in Pancreatic Islets

open access: yesArchivum histologicum japonicum, 1977
A high concentration of gamma-aminobutyric acid (GABA) and a high activity of glutamate decarboxylase (GAD), enzyme for GABA synthesis, were demonstrated in the rat pancreatic islets using a recently developed assay method combining the GABase system with the enzymatic NADP-NADPH cyclin method. Both GABA concentration and GAD activity in the pancreatic
TANIGUCHI, Hiroshi   +3 more
openaire   +3 more sources

Data on morphometric analysis of the pancreatic islets from C57BL/6 and BALB/c mice

open access: yesData in Brief, 2016
The endocrine portion of the pancreas, which is characterized by pancreatic islets, has been widely investigated among different species. The BALB/c and C57BL/6 mice are extensively used in experimental research, and the morphometric differences in the ...
Thiago Aparecido da Silva   +4 more
doaj   +1 more source

Intraperitoneal injection of cell-engineered pancreas in rats with experimental type i diabetes (preliminary results)

open access: yesВестник трансплантологии и искусственных органов, 2023
Creation of a bioartificial pancreas, including a cell-engineered construct (CEC) formed from pancreatic islets (islets of Langerhans) and a biocompatible matrix mimicking the native microenvironment of pancreatic tissue, is one of the approaches to the ...
A. S. Ponomareva   +9 more
doaj   +1 more source

Combining Donor Characteristics with Immunohistological Data Improves the Prediction of Islet Isolation Success

open access: yesJournal of Diabetes Research, 2016
Variability of pancreatic donors may significantly impact the success of islet isolation. The aim of this study was to evaluate donor factors associated with isolation failure and to investigate whether immunohistology could contribute to organ selection.
Zuzana Berkova   +16 more
doaj   +1 more source

Effect of Basic Fibroblast Growth Factor on Insulin Secretion from Microencapsulated Pancreatic Islets: An In Vitro Study

open access: yesCell Transplantation, 2001
Microencapsulation of pancreatic islets represents a potentially effective method to prevent graft rejection in allotransplantation or xenotransplantation without the need of immunosuppression.
Wenjing Wang   +8 more
doaj   +1 more source

Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes—Analysis of the Results of Preclinical Studies on a Mouse Model

open access: yesJournal of Functional Biomaterials, 2023
Recently, tissue engineering, including 3D bioprinting of the pancreas, has acquired clinical significance and has become an outstanding potential method of customized treatment for type 1 diabetes mellitus. The study aimed to evaluate the function of 3D-
Marta Klak   +14 more
doaj   +1 more source

Heterogeneity of the Human Pancreatic Islet [PDF]

open access: yesDiabetes, 2019
Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous in a number of properties such as electrical activity, gene expression, and cell surface markers.
Michael P. Dybala, Manami Hara
openaire   +2 more sources

Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation

open access: yesEndocrine Connections, 2019
Pancreatic islets from pregnant rats develop a transitory increase in the pancreatic β-cell proliferation rate and mass. Increased apoptosis during early lactation contributes to the rapid reversal of those morphological changes.
Caio Jordão Teixeira   +5 more
doaj   +1 more source

Pancreatic Islet Transplantation

open access: yesPLoS Medicine, 2004
Islet transplantation offers hope to many patients with diabetes, who envision a life free of glucose checks and insulin injections. What are the barriers to its widespread implementation?
Mark A Naftanel, David M Harlan
openaire   +4 more sources

Influence of macrophages on the insulin-synthesizing system under normal conditions and in alloxan diabetes

open access: yesМедицинская иммунология, 2023
Insulin-synthesizing cells (ISCs) of pancreatic gland are localized both in its islets, and in exocrine portion, as single cells or cellular agglomerates.
T. S. Bulavintseva   +3 more
doaj   +1 more source

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