Results 41 to 50 of about 53,803 (167)
Cellular Physiology and Biochemistry, 2013 Backgrounds/Aims: Obese rats obtained by neonatal monosodium glutamate (MSG) administration present insulin hypersecretion. The metabolic mechanism by which glucose catabolism is coupled to insulin secretion in the pancreatic β-cells from MSG-treated ...
Nayara de Carvalho Leite +6 more
doaj +1 more source
Molecular Metabolism, 2020 Objectives: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology.
Scott A. Campbell +8 more
doaj +1 more source
Maternal protein malnutrition does not impair insulin secretion from pancreatic islets of offspring after transplantation into diabetic rats. [PDF]
PLoS ONE, 2012 Pancreatic islets from adult rats whose mothers were protein restricted during lactation undersecrete insulin. The current work analyzes whether this secretory dysfunction can be improved when the pancreatic islets are grafted into hyperglycemic diabetic
Renato Chaves Souto Branco +9 more
doaj +1 more source
The Pancreatic Islet Regulome Browser [PDF]
Frontiers in Genetics, 2017 The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas whose primary function is that of controlling glucose homeostasis. Thus, understanding the transcriptional control of islet-cell may help to puzzle out the pathogenesis of glucose metabolism disorders.
Mularoni, Loris +2 more
openaire +5 more sources
AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. [PDF]
PLoS ONE, 2013 The precise role of AMP-activated protein kinase (AMPK), a target of metformin, in pancreatic β cells remains controversial, even though metformin was recently shown to enhance the expression of incretin receptors (GLP-1 and GIP receptors) in pancreatic ...
Kazuki Tajima +13 more
doaj +1 more source
Prediction of Pancreatic Islet Yield After Pancreatectomy Using Optical Coherence Elastography
DiagnosticsIntraoperative assessment of pancreatic quality, followed by sampling for the potential isolation of Langerhans islets for subsequent autotransplantation, is currently a key component of post-total pancreatectomy diabetes mellitus treatment.
Ekaterina Gubarkova +11 more
doaj +1 more source
EMBO Molecular Medicine, 2014 Autoimmune type 1 diabetes (T1D) development results from the interaction between pancreatic β‐cells, and the innate and the adaptive immune systems culminating with the destruction of the insulin‐secreting β‐cells by autoreactive T cells.
Julien Diana, Agnès Lehuen
doaj +1 more source
Heliyon, 2023 Summary: The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets in situ in diabetic rodents by the synchrotron
Qingqing Guo +9 more
doaj +1 more source
BETA2 and Pancreatic Islet Development
Recent Progress in Hormone Research, 2001 The pancreas is essential for digestion and glucose homeostasis. Diseases associated with the pancreas (e.g., pancreatitis, pancreatic cancer, diabetes) are generally debilitating for the patient. Diabetes is particularly prominent in the United States, affecting nearly 6 percent of the population, with associated annual health costs in the billions of
K, Chu, E, Nemoz-Gaillard, M J, Tsai
openaire +2 more sources
Cell Transplantation, 2006 The formation of a new microvasculature is essential for the long-term survival and function of the islet graft. In this study we examined endothelium of isolated pancreatic islets by stimulation with growth factors, different culture conditions, and ...
André Kidszun +9 more
doaj +1 more source