Results 71 to 80 of about 527,417 (294)

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Isolated Pancreatic Islets in Three-Dimensional Matrices are Responsive to Stimulators and Inhibitors of Angiogenesis

Cell Transplantation, 2006
The formation of a new microvasculature is essential for the long-term survival and function of the islet graft. In this study we examined endothelium of isolated pancreatic islets by stimulation with growth factors, different culture conditions, and ...
André Kidszun, Darius Schneider, Doris Erb, Gundula Hertl, Veronika Schmidt, Michael Eckhard, Klaus T. Preissner, Georg Breier, Reinhard G. Bretzel, Thomas Linn M.D., Ph.D   +9 more
doaj   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Pancreatic islets implanted in an irreversible electroporation generated extracellular matrix in the liver

Radiology and Oncology, 2023
Pancreatic islet transplantation via infusion through the portal vein, has become an established clinical treatment for patients with type 1 diabetes. Because the engraftment efficiency is low, new approaches for pancreatic islets implantation are sought.
Zhang Yanfang, Lv Yanpeng, Wang Yunlong, Chang Tammy T, Rubinsky Boris   +4 more
doaj   +1 more source

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

PLoS ONE, 2013
Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility have focused attention on the regulation of transcriptional activity within the pancreatic beta-cell.
M. van de Bunt, K. Gaulton, L. Parts, Ignasi Morán, P. Johnson, C. Lindgren, J. Ferrer, A. Gloyn, M. McCarthy   +8 more
semanticscholar   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

Clinical and Developmental Immunology, 2013
Since the initial reporting of the successful reversal of hyperglycemia through the transplantation of pancreatic islets, significant research efforts have been conducted in elucidating the process of revascularization and the influence of engraftment ...
A. Pepper, B. Gala-Lopez, O. Ziff, A. M. J. Shapiro   +3 more
semanticscholar   +1 more source

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization [PDF]

Diabetes, 2011
OBJECTIVE Freshly isolated pancreatic islets contain, in contrast to cultured islets, intraislet endothelial cells (ECs), which can contribute to the formation of functional blood vessels after transplantation. We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization ...
Nyqvist, D., Speier, S., Rodriguez-Diaz, R., Molano, R. D., Lipovsek, S., Rupnik, M., Dicker, A., Ilegems, E., Zahr-Akrawi, E., Molina, J., Lopez-Cabeza, M., Villate, S., Abdulreda, M. H., Ricordi, C., Caicedo, A., Pileggi, A., Berggren, P.-O.   +16 more
openaire   +2 more sources

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Generation of ARX-T2A-H2B-CFP x C-PEP-mCherry-hiPSC double reporter line for monitoring of pancreatic differentiation

Stem Cell Research
Pancreatic islets consist of several different endocrine cell types that work in harmony. Aside from primary pancreatic islets, stem cell-derived pancreatic islets can be used as an alternative research and disease model.
Eunike Sawitning Ayu Setyono, Nicole Katarina Rogers, Anita Hofmann, Heiko Lickert, Ingo Burtscher   +4 more
doaj   +1 more source