Results 71 to 80 of about 116,954 (354)

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]

, 2016
Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I., Elhachmane, M., Gopel, S., Pedersen, MORTEN GRAM   +3 more
core   +1 more source

Integrated Microfluidic Platform for High‐Throughput Generation of Intestinal Organoids in Hydrogel Droplets

Advanced Science, EarlyView.
ABSTRACT Organoid research offers valuable insights into human biology and disease, but reproducibility and scalability remain significant challenges, particularly for epithelial organoids. Here, we present an integrated microfluidic platform that addresses these limitations by enabling high‐throughput generation of uniform hydrogel microparticles ...
Barbora Lavickova, Hannah Kronabitter, Mar Cervera‐Negueruela, Eylul Ceylan, Laura Benito‐Zarza, Rubén López‐Sandoval, Irineja Cubela, J. Gray Camp, Jose L. Garcia‐Cordero   +8 more
wiley   +1 more source

Prediction of Pancreatic Islet Yield After Pancreatectomy Using Optical Coherence Elastography

Diagnostics
Intraoperative assessment of pancreatic quality, followed by sampling for the potential isolation of Langerhans islets for subsequent autotransplantation, is currently a key component of post-total pancreatectomy diabetes mellitus treatment.
Ekaterina Gubarkova, Ekaterina Vasilchikova, Arseniy Potapov, Denis Kuchin, Polina Ermakova, Julia Tselousova, Anastasia Anina, Liya Lugovaya, Marina Sirotkina, Natalia Gladkova, Aleksandra Kashina, Vladimir Zagainov   +11 more
doaj   +1 more source

Macrophages and β‐cells are responsible for CXCR2‐mediated neutrophil infiltration of the pancreas during autoimmune diabetes

EMBO Molecular Medicine, 2014
Autoimmune type 1 diabetes (T1D) development results from the interaction between pancreatic β‐cells, and the innate and the adaptive immune systems culminating with the destruction of the insulin‐secreting β‐cells by autoreactive T cells.
Julien Diana, Agnès Lehuen
doaj   +1 more source

Reduced volume of diabetic pancreatic islets in rodents detected by synchrotron X-ray phase-contrast microtomography and deep learning network

Heliyon, 2023
Summary: The pancreatic islet is a highly structured micro-organ that produces insulin in response to rising blood glucose. Here we develop a label-free and automatic imaging approach to visualize the islets in situ in diabetic rodents by the synchrotron
Qingqing Guo, Abdulla AlKendi, Xiaoping Jiang, Alberto Mittone, Linbo Wang, Emanuel Larsson, Alberto Bravin, Erik Renström, Xianyong Fang, Enming Zhang   +9 more
doaj   +1 more source

Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. [PDF]

, 2016
Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression
Butte, Atul J, Fathman, C Garrison, Fuhlbrigge, Rebecca, Kodama, Keiichi, Miao, Dongmei, Toda, Kyoko, Yamada, Satoru, Yip, Linda, Yu, Liping, Zhao, Zhiyuan   +9 more
core   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Modeling of reaction-diffusion transport into a core-shell geometry [PDF]

, 2018
Fickian diffusion into a core-shell geometry is modeled. The interior core mimics pancreatic Langerhan islets and the exterior shell acts as inert protection.
Beckman, S., Bratlie, Kaitlin, Bratlie, Kaitlin, Brown, Amelia, King, Clarence, Sargin, Irmak   +5 more
core   +3 more sources

Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats

Animal Models and Experimental Medicine, EarlyView.
The experimental type 2 diabetes model in rats induced by streptozotocin and nicotinamide showed that silver nanoparticles synthesized from lemongrass extract modulate blood glucose, water and food intake, and enhance antioxidant enzyme synthesis and weight gains.
Milad Faraji, Mohammad Foad Noorbakhsh, Nasrin Kazemipour, Saeed Nazifi, Hamid Reza Moradi, Nasrollah Ahmadi, Maryam Azadmanesh   +6 more
wiley   +1 more source

Features of the alpha-cell population organization in pancreas of spontaneously hypertensive rats (SHR)

Patologìâ, 2017
Alpha cells of pancreatic islets constitute the second largest population of pancreatic endocrinocytes, and the glucagon synthesized in them plays an important role in the regulation of glucose homeostasis.
T. V. Abramova, Yu. M. Kolesnyk
doaj   +1 more source