Results 211 to 220 of about 1,457,192 (230)

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance

Aging Cell, Volume 25, Issue 9, September 2026.
Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication. ABSTRACT Cell division inevitably shortens telomeric DNA owing to the end‐replication problem.
Jie Wang, Yuehui Su, Chao Chen, Yueying Li, Jiajia Han, Liping Du, Liyun Zheng, Ya‐Long Dang, Ying Peng   +8 more
wiley   +1 more source

Case Report: Ectopic Cushing's syndrome caused by a pancreatic neuroendocrine tumor managed through dual steroidogenesis inhibition and endoscopic ultrasound-guided ethanol ablation. [PDF]

Front Endocrinol (Lausanne)
Krzystek Ł, Sagan KP, Andrysiak-Mamos E, Retfiński S, Buć K, Marczak W, Brzeska A, Patalong-Wójcik M, Żochowska E, Dąbkowski K, Syrenicz A.   +10 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Exploring the key molecular mechanisms and immune microenvironment of oxidative stress-related pathways in pancreatic neuroendocrine tumor combining scRNA-seq and bulk RNA. [PDF]

Discov Oncol
Cai Z, Li J, Li T, Peng Q.
europepmc   +1 more source

Development and Crossover Evaluation of an Artificial Intelligence‐Assisted System for Solid Pancreatic Lesion Detection and Pancreatic Parenchyma Recognition in Endoscopic Ultrasonography (With Video)

Digestive Endoscopy, Volume 38, Issue 9, September 2026.
Overview of the development and randomized crossover evaluation of an artificial intelligence (AI)‐assisted overlay system for endoscopic ultrasonography (EUS). The system was designed to support detection of solid pancreatic lesions (SPLs) and recognition of pancreatic parenchyma (PP).
Toshio Fujisawa, Takamichi Kuwahara, Tatsuya Sato, Yusuke Takasaki, Nozomi Okuno, Ryunosuke Hakuta, Ko Tomishima, Shin Haba, Naminatsu Takahara, Yukiko Ito, Yousuke Nakai, Kazuo Hara, Hiroyuki Isayama   +12 more
wiley   +1 more source

Endoscopic Papillectomy May Be a Feasible Treatment Option for Elderly Patients With Ampullary Tumors: A Multicenter Retrospective Study

Digestive Endoscopy, Volume 38, Issue 9, September 2026.
Multicenter retrospective analysis of 255 patients undergoing endoscopic papillectomy demonstrated significantly lower rates of delayed bleeding and post‐EP pancreatitis in patients aged ≥ 75 years. Age ≥ 75 75 years was independently associated with reduced risks of both adverse events, while serious complications, complete resection, and recurrence ...
Noriki Kasuga, Yusuke Kurita, Yusuke Sekino, Keiki Nagai, Yuji Fujita, Riko Hemmi, Daiki Imanaga, Manato Kaneda, Shota Matsumoto, Masato Suzuki, Shin Yagi, Kensuke Kubota, Masato Yoneda   +12 more
wiley   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

A Case of Pancreatic Neuroendocrine Tumor Growing Intraductal Extension toward the Main Pancreatic Duct Complicated by Thrombocytopenia: Diagnostic Challenges and Management Strategy. [PDF]

DEN Open
Soga K, Sakakibara K, Soma Y, Shiina M, Yamaguchi M, Kuwada M, Shirahashi R, Kobori I, Ban S, Tamano M.   +9 more
europepmc   +1 more source

In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines—An Exploratory Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Anaesthetic agents are essential for surgical procedures, yet their potential role on tumour cell biology remains incompletely understood. Emerging evidence suggests that these compounds can act both as protumor and antitumor agents, influencing cellular processes such as proliferation, migration and cell death mechanisms.
Olga Grajdieru, Alexandru Cristian Sabo, Adrian Bogdan Tigu, Andrei Ivancuta, Cristian Silviu Moldovan, Andrada Uhl, Miruna Cristina Ungurenasu, Andrada‐Ioana Balmez, Ada Moisescu, Simina Pîrv, Madalina Nistor, Ximena‐Maria Muresan, Diana Cenariu, Ciprian Tomuleasa, Catalin Constantinescu   +14 more
wiley   +1 more source

Surufatinib related nephrotic syndrome in a pancreatic neuroendocrine tumor: a case report and review of literature. [PDF]

Front Oncol
Shi C, Lin J, Xiang X, Bao W, Yang J.
europepmc   +1 more source