Results 121 to 130 of about 1,729,239 (300)

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Multi-omics and spatial transcriptomics decode the ZDHHC9-driven hypoxia-immunosuppressive axis in hepatocellular carcinoma

Frontiers in Oncology
BackgroundHepatocellular carcinoma (HCC) is a major global health challenge with limited treatment options, highlighting the urgent need for new biomarkers and therapeutic targets. Protein palmitoylation, mediated by ZDHHC enzymes, plays a role in cancer,
Haiyan Lu, Lingzhen Kong, Shidong Hu, Wenyuan Xie, Yi Wang, Jianhua Wang, Fengsheng Dai   +6 more
doaj   +1 more source

The role of the tumor microenvironment in the metastasis of pancreatic cancer and immunotherapy

, 2019
Pancreatic cancer is the most aggressive type of cancer, with egregious survival rates, and is notoriously difficult to treat. Patients with pancreatic cancer are generally diagnosed at an advanced stage.

core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension & Cirrhosis
The global landscape of liver cirrhosis has undergone a significant transformation with the widespread implementation of viral vaccines, and metabolic dysfunction‐associated steatotic liver disease (MASLD) cirrhosis has emerged as a predominant etiology.
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
doaj   +1 more source

Comparative analysis of deep learning and radiomics models in predicting hepatocellular carcinoma differentiation via ultrasound

Frontiers in Medicine
ObjectiveThis study aimed to develop and compare predictive models for hepatocellular carcinoma (HCC) differentiation using ultrasound-based radiomics and deep learning, and to evaluate the clinical utility of a combined model.MethodsRadiomics and deep ...
Luohang Xu, Yanhua Huang, Hong Fu, Hong Fu, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu, Yalan Zheng, Jiaxuan Qian, Hongwei Qian, Hongwei Qian   +11 more
doaj   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Pancreatic Divisum Associated with Ampullary Neuroendocrine Tumor and the Role of Magnetic Resonance Imaging

, 2017
Pancreatic divisum is the most common anomaly of the pancreas. Pancreatic divisum associated with malignant tumor is rarely seen. The ampulla of Vater is formed by the union of the common bile duct and the pancreatic duct.
Yaşar Bükte, Fatma Kulalı, Aslıhan Semiz Oysu   +2 more
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Ultrasound-based intratumoral and peritumoral radiomics for preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma

Frontiers in Medicine
BackgroundAccurate preoperative assessment of lymph node metastasis (LNM) in pancreatic ductal adenocarcinoma (PDAC) remains challenging. We developed and compared ultrasound-based intratumoral, peritumoral, clinical, and combined models for LNM ...
Yanhua Huang, Yanhua Huang, Hongwei Qian, Hongwei Qian, Hongwei Qian, Li Bao, Li Bao, Li Bao, Hong Fu, Hong Fu, Hong Fu, Jianhua Yu, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu, Baochun Lu, Zhihong Shen, Zhihong Shen, Zhihong Shen   +19 more
doaj   +1 more source