Results 121 to 130 of about 1,718,006 (300)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Multi-omics and spatial transcriptomics decode the ZDHHC9-driven hypoxia-immunosuppressive axis in hepatocellular carcinoma

Frontiers in Oncology
BackgroundHepatocellular carcinoma (HCC) is a major global health challenge with limited treatment options, highlighting the urgent need for new biomarkers and therapeutic targets. Protein palmitoylation, mediated by ZDHHC enzymes, plays a role in cancer,
Haiyan Lu, Lingzhen Kong, Shidong Hu, Wenyuan Xie, Yi Wang, Jianhua Wang, Fengsheng Dai   +6 more
doaj   +1 more source

The role of the tumor microenvironment in the metastasis of pancreatic cancer and immunotherapy

, 2019
Pancreatic cancer is the most aggressive type of cancer, with egregious survival rates, and is notoriously difficult to treat. Patients with pancreatic cancer are generally diagnosed at an advanced stage.

core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension & Cirrhosis
The global landscape of liver cirrhosis has undergone a significant transformation with the widespread implementation of viral vaccines, and metabolic dysfunction‐associated steatotic liver disease (MASLD) cirrhosis has emerged as a predominant etiology.
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
doaj   +1 more source

Pancreatic Divisum Associated with Ampullary Neuroendocrine Tumor and the Role of Magnetic Resonance Imaging

, 2017
Pancreatic divisum is the most common anomaly of the pancreas. Pancreatic divisum associated with malignant tumor is rarely seen. The ampulla of Vater is formed by the union of the common bile duct and the pancreatic duct.
Yaşar Bükte, Fatma Kulalı, Aslıhan Semiz Oysu   +2 more
core   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Comparative analysis of deep learning and radiomics models in predicting hepatocellular carcinoma differentiation via ultrasound

Frontiers in Medicine
ObjectiveThis study aimed to develop and compare predictive models for hepatocellular carcinoma (HCC) differentiation using ultrasound-based radiomics and deep learning, and to evaluate the clinical utility of a combined model.MethodsRadiomics and deep ...
Luohang Xu, Yanhua Huang, Hong Fu, Hong Fu, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu, Yalan Zheng, Jiaxuan Qian, Hongwei Qian, Hongwei Qian   +11 more
doaj   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Ultrasound-based intratumoral and peritumoral radiomics for preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma

Frontiers in Medicine
BackgroundAccurate preoperative assessment of lymph node metastasis (LNM) in pancreatic ductal adenocarcinoma (PDAC) remains challenging. We developed and compared ultrasound-based intratumoral, peritumoral, clinical, and combined models for LNM ...
Yanhua Huang, Yanhua Huang, Hongwei Qian, Hongwei Qian, Hongwei Qian, Li Bao, Li Bao, Li Bao, Hong Fu, Hong Fu, Hong Fu, Jianhua Yu, Jianhua Yu, Jianhua Yu, Baochun Lu, Baochun Lu, Baochun Lu, Zhihong Shen, Zhihong Shen, Zhihong Shen   +19 more
doaj   +1 more source