Results 101 to 110 of about 1,718,006 (300)

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Strategies, Challenges and Application Prospects for Exosome Engineering Modifications in Tumor Targeted Therapeutics

International Journal of Nanomedicine
Xiaoyan Ge,1,2,* Shuo Shan,1,* Haozhong Lu,2 Weihua Wang,1 Chao Gao,1 Shunli Fu1 1Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, The Affiliated
Ge X, Shan S, Lu H, Wang W, Gao C, Fu S
doaj  

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics
Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide, characterized by dense desmoplastic stroma, profound immunosuppression, and poor responsiveness to conventional therapies.
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
doaj   +1 more source

ICT-Net: An Integrated Convolution and Transformer-Based Network for Complex Liver and Liver Tumor Region Segmentation

IEEE Journal of Translational Engineering in Health and Medicine
Background: Automatic segmentation of liver regions as well as liver lesions such as hepatocellular carcinoma (HCC) from computed tomography (CT) images is critical for accurate diagnosis and therapy planning.
Chukwuemeka Clinton Atabansi, Hui Li, Sheng Wang, Jing Nie, Haijun Liu, Bo Xu, Xichuan Zhou, Dewei Li   +7 more
doaj   +1 more source

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Tumor-infiltrating neutrophils predict poor survival of non-functional pancreatic neuroendocrine tumor. Supplementary material

, 2020
Supplementary material for the manuscript "Tumor-infiltrating neutrophils predict poor survival of non-functional pancreatic neuroendocrine tumor".
Wen-Quan Wang (8631932), Xian-Jun Yu (8631965), Chun-Tao Wu (8631960), Liang Liu (8631968), He-Li Gao (8631934), Hua-Xiang Xu (8631952), Wang Jiang (8631954), Shuai-Shuai Xu (8631938), Xuan Han (8631949), Tian-Jiao Li (8631946), Wuhu Zhang (8631660), Xuan Lin (8631957), Hao Li (8631953), Long-Yun Ye (8631956), Shuo Li (8631941)   +14 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Wireless Precise Manipulation of Tumor Spheroids Using a Millirobot Controlled by Permanent Magnetic Traps

Advanced Robotics Research, EarlyView.
A magnetic donut‐like millirobot is developed for label‐free pick‐and‐place of a tumor spheroid wirelessly controlled by a magnetic trap. Spheroids are important 3D multicellular culture systems that recapitulate key structural and functional features of native tissues.
Yue Gao, Moonkwang Jeong, Anni G. Muñoz, Ann‐Sophia Müller, Fangchao Long, Shengqiang Zhou, Juntian Qu, Leoni A. Kunz‐Schughart, Tian Qiu   +8 more
wiley   +1 more source

From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation

Journal of Multidisciplinary Healthcare
Hui Song,1,* Xiaowu Dong,2,* Qinghui Niu,3 Qian Yu,1 Xiangjia Zhu,4 Hong Zhao,5 Chang Li,6 Guotao Lu,2 Xin Liu7 1Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for ...
Song H, Dong X, Niu Q, Yu Q, Zhu X, Zhao H, Li C, Lu G, Liu X   +8 more
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