Results 81 to 90 of about 1,718,006 (300)

Upregulated Expression of TUBA1C Predicts Poor Prognosis and Promotes Oncogenesis in Pancreatic Ductal Adenocarcinoma via Regulating the Cell Cycle

Frontiers in Oncology, 2020
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease and has the worst prognosis and survival rate. TUBA1C is a microtubule component implicated in multiple cancers, however, the clinical significance and biological functions
Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Piao Zhang, Qiuqiang Zhang, Qiuqiang Zhang, Guoqi Li, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang   +12 more
doaj   +1 more source

Oral capecitabine in gemcitabine-pretreated patients with advanced pancreatic cancer [PDF]

, 2007
Objective: To date, no standard regimen for salvage chemotherapy after gemcitabine (Gem) failure has been defined for patients with advanced pancreatic cancer (PC). Oral capecitabine (Cap) has shown promising activity in first-line chemotherapy trials in
Haas, Michael, Haas, M., Wilkowski, R., Schulz, Christoph, Moosmann, Nicolas, Heinemann, V., Golf, Alexander, Bruns, Christiane J., Laessig, Dorit, Golf, A., Heinemann, Volker, Boeck, S., Moosmann, N., Issels, Rolf-Dieter, Wilkowski, Ralf, Laessig, D., Issels, R.D., Boeck, Stefan, Bruns, C.J., Schulz, C.   +19 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

DCM-Net: dual-encoder CNN-Mamba network with cross-branch fusion for robust medical image segmentation

BMC Medical Imaging
Background Medical image segmentation is a critical task for the early detection and diagnosis of various conditions, such as skin cancer, polyps, thyroid nodules, and pancreatic tumors.
Chukwuemeka Clinton Atabansi, Sheng Wang, Hui Li, Jing Nie, Lei Xiang, Cheng Zhang, Haijun Liu, Xichuan Zhou, Dewei Li   +8 more
doaj   +1 more source

Da Vinci robot-assisted retroperitoneal tumor resection in 105 patients: a single-center experience

Frontiers in Oncology
BackgroundThe Da Vinci Surgical System (DVSS) has the advantages of minimal invasion, rapid recovery, safety, and reliability. Although the DVSS has been widely used in various abdominal surgeries, descriptions of its use in robot-assisted ...
Qisheng Hao, Qisheng Hao, Lichao Cha, Lichao Cha, Bin Zhou, Bin Zhou, Xinyu Li, Xinyu Li, Mingkai Gong, Qingze Li, Qingze Li, Guofei Dong, Mengqi Song, Zehua Wu, Zhongyi Guo, Fabo Qiu, Fabo Qiu, Xiaowei Wang, Lantian Tian, Lantian Tian   +19 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

EGFR‐Targeting IgG1 Antibody Enhances NK Cell‐Mediated Tumor Killing in KRAS‐Mutant Pancreatic Cancer

MedComm
KRAS‐mutant pancreatic ductal adenocarcinoma (PDAC) exhibits intrinsic resistance to epidermal growth factor receptor (EGFR)‐targeted therapies owing to constitutive downstream pathway activation.
Ruoxi Xiao, Xiaoxiao Li, Ping Li, Junjin Wang, Xiaoyuan Sun, Chenyang Zhao, Zimin Liu, Ruining Gong, Minghan Ren, Ke Lei, He Ren   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source