Results 91 to 100 of about 1,729,239 (300)

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Irreversible Electroporation of Pancreatic Tumors

, 2017
Over 95% of pancreatic cancers are exocrine tumors that bare a dismal prognosis. Although oncological outcome is best for patients presenting with nonmetastatic resectable disease, cure is rarely achieved [1]. Up to 40% of patients present with nonmetastatic disease that is considered unresectable due to vascular encasement (locally advanced pancreatic
Meijerink, Martijn R., Nilsson, Anders, Narayanan, Govindarajan, Martin, Robert   +3 more
openaire   +4 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Integrating intratumoral, peritumoral, and clinical features in an ultrasound-based radiomics model: contributions and synergies for predicting microvascular invasion in hepatocellular carcinoma

Frontiers in Oncology
BackgroundMicrovascular invasion (MVI) is a critical determinant of poor prognosis in hepatocellular carcinoma (HCC). Accurate preoperative prediction of MVI is essential for optimizing surgical and therapeutic strategies.
Hong Fu, Hong Fu, Yanhua Huang, Baochun Lu, Baochun Lu, Jianhua Yu, Jianhua Yu, Difan Zhou, Difan Zhou, Chuanling Hou, Luohang Xu, Hongwei Qian, Hongwei Qian   +12 more
doaj   +1 more source

Tumors of the pancreatic islets [PDF]

Cancer, 1960
J, SIERACKI, R B, MARSHALL, R C, HORN
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Efficacy and conversion outcome of chemotherapy combined with PD-1 inhibitor for patients with unresectable or recurrent gallbladder carcinoma: a real-world exploratory study

World Journal of Surgical Oncology
Background Gallbladder carcinoma (GBC) is an extremely aggressive tumor of the biliary tract with a bleak prognosis, and the evidence supporting the benefit of available systemic therapy for advanced GBC is scarce.
Qin-qin Liu, Jian Yan, Yan-fang Ye, Cai-ni Yang, Zhi-jun Chen, Hao-ming Lin, Zi-tong Zhang, Rui Zhang   +7 more
doaj   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

Advanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran, Thi Tu Uyen Phan, Michael Baboudjian, Quang Hieu Duong, Ines Sousa, Thi Thuy Le, Virginie Baylot, Sophie Giusiano, Laurent Daniel, Pauline Brige, Benjamin Guillet, Cyrille Bastide, Carmen Garrido, David Taïeb, Thi Khanh Le, Palma Rocchi   +15 more
wiley   +1 more source

Diabetes mellitus associated with pancreatic somatostatin tumor: A case report

Journal of Clinical and Translational Endocrinology Case Reports, 2016
The finding of diabetes in association with a pancreatic neuroendocrine tumor (PNET) in patients is uncommon. Here, we describe a 74-year-old diabetes patient with a tumor in the pancreatic head.
Bing Han, MD, Hualin Zhai, MD, Jiao Yu, MD, Fangzhen Xia, MD, Yingli Lu, MD   +4 more
doaj   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source