Results 111 to 120 of about 1,718,006 (300)

Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities

Frontiers in Oncology
In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which
Hongliang Liu, Xi Wang, Lingyan Liu, Bingsong Yan, Fabo Qiu, Bin Zhou   +5 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis

Signal Transduction and Targeted Therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis, particularly in the presence of liver metastases. The mechanisms by which metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as
Qian Yu, Hui Song, Xiao-ya Shi, Liang Zhu, Yu Liang, Rui-ning Gong, Xiao-wu Dong, Shang-long Liu, Hai-zhen Wang, Ying-luo Wang, Jiu-fa Cui, Xiao-nan Yang, Ying Chen, Chao Gao, Zhan Yang, Qing-tian Zhu, Chang Li, Huan Zhang, Jie-er Ying, Mei-fang Zheng, Yan-tao Tian, Hai-tao Hu, Xin-xin Shao, Yue Li, Ming-guang Mo, Yun Lu, Zheng Ma, Shun-li Fu, Qing-hui Niu, Yuan-yu Liao, Chen-yang Zhao, Xin Liu, Ashok K. Saluja, Ji-gang Wang, Xiao-yu Li, Song-yue Guo, Wei-hua Wang, Song Wang, Bin Liu, Guo-tao Lu, He Ren   +40 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation [PDF]

, 2014
Sandeep S Hedgire,1 Mari Mino-Kenudson,2 Azadeh Elmi,1 Sarah Thayer,3 Carlos Fernandez-del Castillo,3 Mukesh G Harisinghani11Department of Abdominal Imaging and Intervention, 2Department of Pathology, 3Department of Surgery, Massachusetts General ...
Hedgire SS, Mino-Kenudson M, Thayer S, Elmi A, Harisinghani MG, Fernandez-del Castillo C   +5 more
core  

Gender differences in tumor characteristics, treatment allocation and survival in stage I–III pancreatic cancer:a nationwide study [PDF]

Introduction: Sex and gender are modulators of health and disease and may have impact on treatment allocation and survival in patients with cancer. In this study, we analyzed the impact of sex and gender on treatment allocation and overall survival in ...
van Eijck, C. H.J., van Eijck, CHJ, Besselink, M.G., Wilmink, J. W., van der Geest, L. G., Wagner, A.D., Besselink, M. G., Gehrels, A.M., Wagner, A. D., Wilmink, J.W., Verhoeven, R. H.A., Gehrels, A. M., van der Geest, L.G., Verhoeven, RHA, van Laarhoven, H. W.M., van Laarhoven, HWM   +15 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms

Frontiers in Immunology
BackgroundHepatocellular carcinoma (HCC) lacks reliable prognostic biomarkers for immunotherapy. Immunogenic cell death (ICD) represents a promising therapeutic target, but its comprehensive characterization in HCC remains unexplored.MethodsWe performed ...
Hongliang Liu, Hongliang Liu, Zhenni Sun, Xi Wang, Bin Zhou, Bin Zhou, Lichao Cha, Lichao Cha   +7 more
doaj   +1 more source

Pancreatic secretory trypsin inhibitor stimulates the growth of rat pancreatic carcinoma cells [PDF]

, 1990
Pancreatic secretory trypsin inhibitor was examined for growth-promoting activity on five cell lines using standard cell culture techniques. One cell line, AR4-2J, derived from a rat pancreatic acinar cell carcinoma, responded with significantly ...
Curry, B J, Calam, J, Freeman, T C, Woodburn, J R   +3 more
core