Results 161 to 170 of about 1,729,239 (300)

Pancreatic tumor detection in computed tomography images through a rotary positional siamese vision transformer. [PDF]

Sci Rep
Abinaya M, Kalamani M, Haritha J.
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Obesity and diabetes associated with dysregulation of mevalonate pathway markers and progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor. [PDF]

Stem Cell Res Ther
Rezagholizadeh F, Rokn S, FakherBaheri M, Taherian Z, Rostami H, Azmoudeh-Ardalan F, Rahimi M, Wadji MB, Kashanizadeh A, Eghtedari S, Lotfalizadeh A, Sharifi-Zarchi A, Safari E, Joghataei MT.   +13 more
europepmc   +1 more source

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo. [PDF]

Adv Sci (Weinh)
Cabral FV, Quilez-Alburquerque J, Mooradian O, Vytheswarran S, Parshad B, Obaid G, Huang HC, Hasan T.   +7 more
europepmc   +1 more source

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

Advanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth. [PDF]

Mol Cancer Ther
Ahmad M, Alvi SS, Ahsan H, Perez C, Massey A, Kashyap VK, Chauhan N, Anning E, Tripathi MK, Kim DJ, Sahoo N, Oraby T, Yallapu MM, Khan MM, Sebastian MM, Chauhan SC, Hafeez BB.   +16 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

VISTA drives pancreatic tumor progression through modulation of the tumor-associated macrophage polarity. [PDF]

Nat Commun
Shin SK, Kim G, Park SM, Seo EB, Ye SK, Kang GH, Jung K, Shin HM, Kim HR, Lee DS.   +9 more
europepmc   +1 more source

Evaluation of malignant pancreatic tumor using artificial acoustic radiation force ultrasonography in patients undergoing pancreatectomy

, 2016
To evaluate pancreatic elasticity and tumor diagnosis, we preoperatively investigated the elasticity calculated by a new ultrasonography (US) technique, acoustic radiation force impulse (ARFI).
Nanashima, Atsushi, Murakami, Goushi, Arai, Junichi, Nagayasu, Takeshi, Sakamoto, Ichiro, Sakamoto, Ayami, Hayashi, Hideyuki, Wada, Hideo, Sumida, Yorihisa   +8 more
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