Results 171 to 180 of about 1,729,239 (300)

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response. [PDF]

J Immunother Cancer
Tesfay MZ, Cios A, Cheng Z, Ferdous KU, Shelton RS, Mustafa B, Elliott NM, Raupach EA, Simoes CC, Miousse IR, Urbaniak A, Bauer MA, Siegel ER, Post SR, Chamcheu JC, Govindarajan R, Grdzelishvili VZ, Cannon MJ, Fernandez-Zapico ME, Basnakian AG, Chabu CY, Moaven O, Borad MJ, Nagalo BM.   +23 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Prehabilitation as a Biologically Active Intervention Is Associated with the Remodeling of the Pancreatic Tumor-Immune Microenvironment. [PDF]

Int J Mol Sci
Stubbins R, Li B, Vasquez M, Gorman BK, Zambelas J, Allenson K, Dhala A, Dong W, Zhao H, Wong S.   +9 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

What's on the menu?: metabolic constraints in the pancreatic tumor microenvironment. [PDF]

J Clin Invest
Sheehan C, Muir A.
europepmc   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Corrigendum: The role of microtubules in pancreatic cancer: therapeutic progress

Frontiers in Oncology
Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Bulat Abdrakhimov, Guo-Qi Li, Guo-Qi Li, Xiaohu Zhou, Xiaohu Zhou, Dongkai Zhou, Dongkai Zhou, Hao Xu, Hao Xu, Huixiao Qian, Huixiao Qian, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang   +19 more
doaj   +1 more source

An unusual pancreatic tumor with prominent calcification in a middle-aged man: what is the diagnosis? [PDF]

Clin Endosc
Ishikawa S, Koizumi M, Kokubu M, Numata Y, Kumagi T, Hiasa Y.   +5 more
europepmc   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source