Results 221 to 230 of about 552,612 (348)

Uncertainty-guided pancreatic tumor auto-segmentation with Tversky ensemble. [PDF]

Phys Imaging Radiat Oncol
Yu C, Gay SS, Gupta AC, Martin-Paulpeter RM, Ludmir EB, Zhao Y, Duryea J, Chen X, Cardenas CE, Yang J, Koong AC, Netherton TJ, Rhee DJ, Court LE.   +13 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Microbiological colonization of the pancreatic tumor affects postoperative complications and outcome after pancreatic surgery. [PDF]

Front Cell Infect Microbiol
Biesel EA, Sundheimer J, Badr MT, Posadas-Cantera S, Chikhladze S, Fichtner-Feigl S, Wittel UA.   +6 more
europepmc   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor. [PDF]

PLoS One
Suzuki Y, Sugimori M, Kanemaru Y, Onodera S, Tsuchiya H, Ikeda A, Ikeda R, Goda Y, Kaneko H, Irie K, Sue S, Ijichi H, Maeda S.   +12 more
europepmc   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts. [PDF]

Sci Rep
Chiang S, Garcia Netto K, Kokkinos J, Haghighi KS, Raina AS, Youkhana J, Pitiyarachchi O, Truong Q, Wenholz D, Wilkinson J, Laczka O, Li X, Aldilla VR, Kumar N, Goldstein D, Sharbeen G, Phillips PA.   +16 more
europepmc   +1 more source

Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate [PDF]

, 2004
Caio M. Rocha Lima, Mark R. Green, Robert Rotche, Wilson H. Miller, G. Mark Jeffrey, Laura A. Cisar, A. Morganti, Nicoletta Orlando, G. Gruia, Langdon L. Miller   +9 more
openalex   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Folate- and aCD47-functionalized lipid nanoparticles efficiently deliver mRNA and remodel pancreatic tumor microenvironment.

Biomed Pharmacother
Parés M, Martínez-Latorre J, Candela-Noguera V, Soriano-Teruel PM, García-Fernández A, Pallaruelo-Santamaría V, Aznar E, Martínez-Máñez R, Fillat C.   +8 more
europepmc   +1 more source