Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]
, 2018 Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder +13 more
core +3 more sources
Advanced Science, EarlyView.This work introduces an electrochemical sensing method that employs an innovative platform based on metal‐organic framework (MOF) for detecting biomarkers. The platform integrates an antifouling surface, oriented antibody immobilization, and an enhanced electron transfer layer.
Wenjuan Yang +10 more
wiley +1 more source
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source
Selection criteria for preoperative endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy and endoscopic treatment of bile duct stones. Results of a retrospective; single center study between 1996-2002 [PDF]
, 2004 AIM: The optimal treatment for bile duct stones (in terms of cost, complications and accuracy) is unclear. The aim of our study was to determine the predictive factors for preoperative endoscopic retrograde cholangiopancreatography (ERCP).
Lakatos, László +4 more
core +1 more source
CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance
Advanced Science, EarlyView.Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li +8 more
wiley +1 more source
Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research
Frontiers in Physiology, 2020 Acute pancreatitis is a potentially severe inflammatory disease that may be associated with a substantial morbidity and mortality. Currently there is no specific treatment for the disease, which indicates an ongoing demand for research into its ...
Xinmin Yang +7 more
doaj +1 more source
Cytological Findings of 140 Bile Samples from Dogs and Cats and Associated Clinical Pathological Data [PDF]
, 2015 BACKGROUND: Cholecystocentesis can be part of the diagnostic workup of hepatobiliary disease in small animals, but literature on cytological evaluation of bile is scant.
Boomkens +16 more
core +1 more source
Advanced Science, EarlyView.A personalized nanovaccine combining PLGA‐encapsulated heat‐inactivated CVB3 and membranes from CVB3‐infected breast cancer cells stimulates potent antitumor immunity. It reduces immunosuppressive markers, enhances immune activation, and improves survival in vivo.
Amirhossein Bahreyni +6 more
wiley +1 more source
SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
Advanced Science, EarlyView.Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang +21 more
wiley +1 more source
Journal of PancreatologyBackground:. Acute pancreatitis (AP) is a common condition encountered during clinical practice; 20% of patients have pancreatic necrosis, and the mortality is high.
Yue Wu, JiongDi Lu, Feng Cao, Fei Li
doaj +1 more source