Results 31 to 40 of about 13,127 (165)
British Journal of Clinical Pharmacology, EarlyView.Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller +9 more
wiley +1 more source
Frontiers in Medicine, 2018 Background: Liver transplant recipients are frequently treated with proton pump inhibitors. Drug interactions have been described especially with respect to omeprazole.
Sebastian C. B. Bremer +12 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire +3 more
wiley +1 more source
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
Acta Medica Iranica, 2023 The widespread inappropriate use of intravenous (IV) pantoprazole, due to its high cost, is a substantial issue. To improve its rational use, an order entry form (OEF) based on the institutional guideline, was implemented.
Maryam Taghizadeh-Ghehi +5 more
doaj +1 more source
Journal of Periodontology, EarlyView.Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood +3 more
wiley +1 more source
Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report
Journal of Pharmacy Practice and Research, EarlyView.Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring +3 more
wiley +1 more source
How I Do It: A Novel Case Series of Office‐Based Laser Complete Excision of Vocal Fold Cysts
The Laryngoscope, EarlyView.Office‐based complete excision of vocal fold cysts using Trublue laser via transnasal flexible endoscopy is a technically feasible alternative to conventional marsupialization, enabling en bloc removal under local anesthesia with excellent procedural tolerability.
Aurora Ka Yue Tam +5 more
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Cell Proliferation, EarlyView.Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Proton-pump inhibitor-induced bone loss is preventable by concomitant use of a long-acting somatostatin analogue [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Long-term consumption of pump inhibitors causes osteoporosis. Some possible mechanisms are gastrin over-secretion and hypochlorhydria. Octreotide is a somatostatin analog that inhibits the secretion of many hormones such as gastrin.
Farhad Koohpeyma +2 more
doaj +1 more source
Equine Veterinary Education, EarlyView.Summary Gastroduodenal ulcer disease with secondary stricture formation of the proximal duodenum and portal gas accumulation is described in a neonatal foal. Conventional diagnostics were performed to reach a diagnosis, including gastroscopy, ultrasonography and positive contrast radiography. In addition, a post‐mortem CT was acquired with the contrast
R. F. Dash +3 more
wiley +1 more source