Results 171 to 180 of about 3,413 (197)

Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury. [PDF]

Am J Physiol Renal Physiol
Poudel N, Zheng S, Skrypnyk N, Sung SJ, Goggins E, Nash WT, Pavelec C, Yee M, Balogun I, Medina CB, Yao J, Rosin DL, Leitinger N, Ravichandran KS, Okusa MD.   +14 more
europepmc   +1 more source

Oocyte gene mutations increase rates of total fertilization failure: a systematic review and meta-analysis. [PDF]

Reprod Biol Endocrinol
Kepkep B, Botos MS, Yazıcı İ, Frivaldszky L, Rancz A, Hegyi P, Ács N, Melczer Z, Szentes B, Sipos M.   +9 more
europepmc   +1 more source

ATP-release pannexin channels are gated by lysophospholipids. [PDF]

Elife
Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T.   +11 more
europepmc   +1 more source

Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and 10Panx1 Peptides

International Journal of Molecular Sciences, 2023
Cx43 hemichannels (HCs) and Panx1 channels are two genetically distant protein families. Despite the lack of sequence homology, Cx43 and Panx1 channels have been the subject of debate due to their overlapping expression and the fact that both channels present similarities in terms of their membrane topology and electrical properties.
Alessio Lissoni, Siyu Tao, Katja Witschas   +2 more
exaly   +4 more sources

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A novel heterozygous variant in PANX1 is associated with oocyte death and female infertility

Journal of Assisted Reproduction and Genetics, 2022
Oocyte death is a severe clinical phenotype that causes female infertility and recurrent in vitro fertilization and intracytoplasmic sperm injection failure. We aimed to identify pathogenic variants in a female infertility patient with oocyte death phenotype.Sanger sequencing was performed to screen PANX1 variants in the affected patient.
Jun Tan
exaly   +3 more sources

Double deletion of Panx1 and Panx3 affects skin and bone but not hearing

Journal of Molecular Medicine, 2019
Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes.
Silvia Peñuela
exaly   +7 more sources

Homozygous variants in PANX1 cause human oocyte death and female infertility

European Journal of Human Genetics, 2021
PANX1, one of the members of the pannexin family, is a highly glycosylated channel-forming protein. Recently, we identified heterozygous variants in PANX1 that follow an autosomal dominant inheritance pattern and cause female infertility characterized by oocyte death. In this study, we screened for novel PANX1 variants in patients with the phenotype of
Weijie Wang, Ronggui Qu, Qian Dou
exaly   +3 more sources

Destination and consequences of Panx1 and mutant expression in polarized MDCK cells

Experimental Cell Research, 2019
The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the fate of GFP-tagged Panx1.
Qing Shao, Patrick Lajoie, Dale W Laird   +2 more
exaly   +3 more sources