Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel. [PDF]
Front ImmunolLiu Y +5 more
europepmc +1 more source
Spinal NLRP3 blockade reverses morphine-prolonged neuropathic pain and proinflammatory immune actions in prenatal alcohol-exposed male mice. [PDF]
NeuropharmacologyPasmay AA +4 more
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Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and 10Panx1 Peptides
International Journal of Molecular Sciences, 2023 Cx43 hemichannels (HCs) and Panx1 channels are two genetically distant protein families. Despite the lack of sequence homology, Cx43 and Panx1 channels have been the subject of debate due to their overlapping expression and the fact that both channels present similarities in terms of their membrane topology and electrical properties.
Luc Leybaert +2 more
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A novel heterozygous variant in PANX1 is associated with oocyte death and female infertility
Journal of Assisted Reproduction and Genetics, 2022Oocyte death is a severe clinical phenotype that causes female infertility and recurrent in vitro fertilization and intracytoplasmic sperm injection failure. We aimed to identify pathogenic variants in a female infertility patient with oocyte death phenotype.Sanger sequencing was performed to screen PANX1 variants in the affected patient.
Jun Tan
exaly +3 more sources
Double deletion of Panx1 and Panx3 affects skin and bone but not hearing
Journal of Molecular Medicine, 2019 Pannexins (Panxs), large-pore channel forming glycoproteins, are expressed in a wide variety of tissues including the skin, bone, and cochlea. To date, the use of single knock-out mouse models of both Panx1 and Panx3 have demonstrated their roles in skin development, bone formation, and auditory phenotypes.
Silvia Peñuela
exaly +5 more sources
Destination and consequences of Panx1 and mutant expression in polarized MDCK cells
Experimental Cell Research, 2019The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the fate of GFP-tagged Panx1.
Qing Shao +2 more
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Homozygous variants in PANX1 cause human oocyte death and female infertility
European Journal of Human Genetics, 2021PANX1, one of the members of the pannexin family, is a highly glycosylated channel-forming protein. Recently, we identified heterozygous variants in PANX1 that follow an autosomal dominant inheritance pattern and cause female infertility characterized by oocyte death. In this study, we screened for novel PANX1 variants in patients with the phenotype of
Shujia Zhu, Li Jin, Ronggui Qu
exaly +3 more sources
A novel heterozygous variant in PANX1 causes primary infertility due to oocyte death
Journal of Assisted Reproduction and Genetics, 2022Variants in the pannexin1 (PANX1) gene have been reported to be associated with oocyte death and recurrent in vitro fertilization failure. In this study, we performed genetic analysis in the patient with female infertility due to oocyte death to identify the disease-causing gene variant in the patient.We characterized one patient from a non ...
Meng Wang, Lei Jin, Lixia Zhu
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Sleep-wake cycle and experimental models of Panx1 mutations
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2018To test the hypothesis of a possible role of the Panx1 (pannexin-1) mutation in changing the sleep - wake cycle.Continuous 24 h recording of the EEG and movement activity in Panx1 knockout and wild type mice was performed.A significant increase in wake percentage at the expense of a decrease in slow-wave sleep was found in knockout mice as compared to ...
V M, Kovalzon +3 more
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Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels
Science, 2013How Migraine Develops Migraine is a common medical disorder. Unfortunately, how and why migraine headache is initiated is unclear. Karatas et al. (p. 1092 ) now describe
ERDENER, ŞEFİK EVREN +6 more
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