Panx1 - Open Access .click

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[Distribution and regulation of Panx1 protein].

Sheng li ke xue jin zhan [Progress in physiology], 2014
Pannexin1 (Panx1) is a subtype of the newly discovered gap junction proteins named Pannexin(s). Panx1 is widely expressed in the nervous system, cardiovascular system, etc and can form non-selective and large conductance hemichannel. It has been demonstrated that various conditions can regulate Panx1 open and affect the body's physiological function ...
Xiang-Xing, Kong +3 more
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The Sleep–Waking Cycle and Experimental Models of Mutations in the Panx1 Gene

Neuroscience and Behavioral Physiology, 2019
Objectives. To confirm the authors’ previous suggestion that mutations in the Panx1 gene (pannexin-1) may play an important role in the development of impairments to the sleep-waking cycle. Materials and methods. Studies were carried out using mice with knockout of the Panx1 gene.
Vladimir Kovalzon
exaly +2 more sources

Panx1 as a potential therapeutic target for cardiac ischemia/reperfusion injury

2022
Cardiovascular disease (CVD) is recognized as a major cause of death worldwide. Restriction of the blood supply leads to detrimental effects within the myocardium, which are paradoxically exacerbated upon reperfusion. Few therapeutic strategies are available up to date, yet none of the treatment is efficient enough to abolish ischemia/reperfusion (I/R)
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Conformational rearrangements associated with Panx1 channel gating