Results 101 to 110 of about 51,627 (231)
Glia, Volume 74, Issue 9, September 2026.Activated microglia‐derived inflammatory signals drive astrocytic Piezo1 expression in both in vitro and in vivo models. Piezo1 upregulation modulates astrocytic Ca2+ dynamics and inflammatory gene expression, thereby limiting microglial activation. ABSTRACT Structural tissue alterations in numerous brain disorders can initiate mechanosensory signaling
Yanyang Bai +8 more
wiley +1 more source
Quality‐driven reformulation of Plantago ovata enriched non‐fermented beef salami
Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7245-7256, September 2026.Abstract BACKGROUND Plantago ovata (psyllium) is a hydrocolloid additive that is used widely in foods; however, meat applications of this bioactive ingredient are limited. This study evaluated the effects of 0% to 5% Plantago husk on non‐fermented beef salami during 60 days of storage. Proximate composition, physicochemical properties, texture profile,
Tulay Elal Mus +6 more
wiley +1 more source
Legume Science, Volume 8, Issue 3, September 2026.ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid +4 more
wiley +1 more source
The C117D oxidation mimic reveals the monomeric structure of SARS‐CoV‐2 main protease
Protein Science, Volume 35, Issue 9, September 2026.Abstract The SARS‐CoV‐2 main protease (Mpro) is essential for viral replication and functions as a homodimer, with dimerization being critical for catalytic activity. Mpro contains an unusually high number of cysteine residues. Among these, C117 and the catalytic nucleophile C145 can form a reversible disulfide bond under oxidative conditions.
Sam Andress +2 more
wiley +1 more source
Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex of <i>Carica papaya</i> L. [PDF]
EFSA JEFSA Panel on Food Enzymes (FEZ) +15 more
europepmc +3 more sources
Edible Insect Allergens: An Emerging Food Safety Challenge
Sustainable Food Proteins, Volume 4, Issue 3, September 2026.Allergic responses to edible insects arise via two main pathways: cross‐reactivity with homologous arthropod allergens and primary sensitization to edible insect proteins, both leading to IgE‐mediated immune activation. ABSTRACT Edible insects are increasingly promoted as sustainable protein sources; however, their allergenic potential remains a ...
Changqi Liu +5 more
wiley +1 more source
NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana
New Phytologist, Volume 251, Issue 5, Page 2741-2752, September 2026.Proteomic analysis revealed that receptor kinases (red) accumulate higher in rd21 knockout Nicotiana benthamiana plants. Summary RD21‐like proteases are papain‐like cysteine proteases with a C‐terminal granulin domain that are abundant and ubiquitous in angiosperms and have often been implicated in immunity.
Alice Godson +13 more
wiley +1 more source
Exploration of Nirmatrelvir Derivatives as Optimized SARS‐CoV‐2 Antivirals
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Structure‐guided optimization of nirmatrelvir identifies aldehyde and dichloroacetamide warheads and a potency‐enhancing S4 thioamide. Crystal structures reveal an S2 rearrangement extending toward Cys44, suggesting a new covalent‐design opportunity.
Yugendar R. Alugubelli +13 more
wiley +1 more source
A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair
Advanced Healthcare Materials, Volume 15, Issue 29, 7 August 2026.An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret +6 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang +7 more
wiley +1 more source