Results 111 to 120 of about 51,553 (242)

Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development

open access: yesClinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Activated keratinocytes play an important role in the early stage of the pathophysiology of secondary lymphedema through PAR2 signaling. Lymphatic injury‐induced protease activation stimulates keratinocyte PAR2 signaling, driving hyperkeratosis and Th2 inflammation, which can be therapeutically attenuated by teriflunomide. Abstract Background Secondary
Hyeung Ju Park   +18 more
wiley   +1 more source

Recent Progress on Enzyme Immobilization: Materials, Strategies, and Applications

open access: yesFood Bioengineering, Volume 5, Issue 2, Page 220-243, June 2026.
Enzyme immobilization technology has undergone substantial evolution driven by advances in materials science. This review systematically examines the recent advances in enzyme immobilization since 2024, with a focused analysis of five major categories of enzyme carriers including covalent organic framework, metal‐organic frameworks, polymers, carbon ...
Shuran Wang   +7 more
wiley   +1 more source

A Review of Extraction, Structural Properties, Biological Activities of Dendrobium chrysotoxum Polysaccharides

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Overview of extraction, biological activities, and application prospects of DCP. (a) Collection, weighing, shearing, and grinding of D. chrysotoxum stems. (b) Aqueous extraction, ultracentrifugation, drying, and filtration to obtain purified DCP. (c) Mechanistic studies and preclinical or retrospective clinical investigations of DCP bioactivities.
Xingshuai Zhang   +4 more
wiley   +1 more source

Structural Characterization and Hypoglycemic Effects of a Purified Polysaccharide From Cinnamomum cassia

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
CCP1A, a polysaccharide purified from Cinnamomum cassia with a molecular weight of approximately 8.16 kDa and rich in glucose and galacturonic acid, exerts anti‐type 2 diabetes effects through a multi‐target synergistic mechanism. On one hand, it delays intestinal glucose absorption by inhibiting the activities of α‐amylase and α‐glucosidase in the ...
Liquan Zhou   +6 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

open access: yesGlia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro   +4 more
wiley   +1 more source

Metabolic Reprogramming and Exosome Remodeling in an Ndufs4‐Deficient Model of Leigh Syndrome

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
Ndufs4 knockout drives exosomal remodeling, reprograms cellular metabolism, impairs neural stem cell self‐renewal and differentiation, and suppresses mTOR signaling, providing a conceptual framework for understanding Leigh syndrome pathogenesis and informing therapeutic development.
Yakun Liu   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy