Results 91 to 100 of about 51,627 (231)

Chemical agents to control biofilm formation in step 1 of care—Toothpastes and mouthwashes/concepts and challenges

Periodontology 2000, EarlyView.
Abstract Maintaining optimal oral hygiene is important for overall oral care, ensuring the well‐being of teeth and their surrounding tissues. In addition, it promotes fresh breath and a pleasing smile. A key element of oral self‐care is the daily use of toothpaste during regular brushing.
Maud Joosstens, Cees Valkenburg, Fridus Van der Weijden   +2 more
wiley   +1 more source

IrregulAB: An open‐source rule‐based engine for automated red cell antibody panel interpretation

Transfusion, EarlyView.
Abstract Background Interpretation of antibody identification panels remains a manual, expertise‐intensive step in transfusion testing; interpretive errors and long turnaround times persist even in well‐equipped hospitals. Existing commercial software is closed source and often omits enzyme‐phase, cold‐phase, and dosage‐sensitive exclusion rules ...
Davide Crucitti, Violeta Vidal Ballester, Jesús Gómez Fernández, Eugenia Fernandez Mellid, Angie Lizeth Ruge Perdomo, Carlos Pérez Míguez, Adrián Mosquera Orgueira   +6 more
wiley   +1 more source

Interpreting antibody identification tests with large language models: Critical role of tabular data formatting

Transfusion, EarlyView.
Abstract Background Antibody identification testing is essential for preventing hemolytic transfusion reactions from unexpected red cell antibodies. Although automated interpretation is desirable to improve efficiency and consistency, conventional algorithmic approaches show limited accuracy, particularly in complex cases.
Jiwoo Lee, Yousun Chung, Dae‐Hyun Ko, Eun Young Song, Hyungsuk Kim   +4 more
wiley   +1 more source

Exploration of a mutant enzyme protein with active site fluctuations at 330 K via machine learning and molecular dynamics simulations

AIP Advances
Control of active site fluctuations in enzyme proteins would significantly expand their application fields. Because papain typically has higher activity at 330 K, shifting the temperature to 330 K may help to expand its range of use in medical treatment,
Katsuhiko Nishiyama
doaj   +1 more source

Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss

Experimental Physiology, EarlyView.
Abstract Repurposing clinically approved antifibrotic agents presents a potential near‐term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We hypothesized that daily oral administration of pirfenidone, an FDA‐approved antifibrotic, would mitigate
Jessica M. Motherwell, Ondine Eken, Claudia E. Hernandez, Christopher L. Dearth, Stephen M. Goldman   +4 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

The Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu, Eduardo Bravo, George Bradley Richerson   +2 more
wiley   +1 more source

Structural Characteristics and Immunoregulatory Effects of Colla Corii Asini Peptides with Iron‐Chelating Capacity

Food Frontiers, Volume 7, Issue 5, September 2026.
Ejiao peptides were fractionated to iron‐chelating F2 (enriched in E‐Xn‐P motif), which restored immune function in CTX‐induced immunosuppressed mice via synergistic regulation of immunity and iron homeostasis. ABSTRACT Iron homeostasis is closely related to immune function, yet the structural basis of food‐derived peptides that modulate this iron ...
Qing‐Tao Zhan, Zi‐Wei Zhao, Jian‐Hang Cai, Xue‐Mei Ge, Shuang‐Di Chen, Xue Tang, Xue‐Ying Ma, Liu‐Ping Fan, Issoufou Amadou, Xiang‐Rong Cheng   +9 more
wiley   +1 more source

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source