Results 121 to 130 of about 63,884 (240)

Pretransfusion testing interference profile of IMC‐002: A novel anti‐CD47 monoclonal antibody engineered for minimized red cell binding

Transfusion, EarlyView.
Abstract Background CD47‐targeted agents can interfere with pretransfusion testing due to CD47 expression on red blood cells (RBCs). IMC‐002 is a novel anti‐CD47 human IgG4 monoclonal antibody engineered to minimize RBC binding; however, its interference profile during pretransfusion testing remains poorly characterized.
Tae‐Shin Kim, Jae Hyeon Park, Yousun Chung, Dae‐Hyun Ko, Seon Young Kim, Hyungsuk Kim   +5 more
wiley   +1 more source

A PIGG congenital disorder of glycosylation (PIGG‐CDG) variant associated with an Emm− red blood cell phenotype in a pediatric patient

Transfusion, EarlyView.
Abstract Background The high‐prevalence Emm antigen is an epitope on the GPI (glycosylphosphatidylinositol) glycolipid backbone, which anchors proteins to the cell surface. Inherited loss‐of‐function of PIGG (or PIGO) results in the rare Emm− red cell (RBC) phenotype and is associated with congenital disorders of glycosylation (CDG).
Alastair Murray, Connie M. Westhoff, Sunitha Vege, Hallie Lee‐Stroka, Randall W. Velliquette, William J. Lane, Jillian G. Buchan, Nabiha H. Saifee, Rida A. Hasan   +8 more
wiley   +1 more source

The effect of thiol compounds on the autolysis of papain

, 1980
Incubation of papain with 3–17.5 mM dithiothreitol and dithioerythritol at pH 8.5 causes inactivation owing to autolysis. Such inactivation is not observed on incubation with equivalent concentrations of mercaptoethanol, cysteine or 2, 3 ...
Wijdenes, J., Sluyterman, L.A.A.E.
core   +1 more source

Identification of a novel high‐prevalence red blood cell antigen on junctional adhesion molecule‐A defines a new blood group system

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Availability of new technologies has accelerated the pace of blood group discovery, with nine of 48 known systems being discovered in the past 5 years alone, and yet uncharacterized antigens remain. This study involved investigations of samples from a female patient presenting with a moderate strength pan‐reactive ...
Tosti J. Mankelow, Louise A. Tilley, Vanja Karamatic Crew, Benjamin Jones, Marina Izak, Liora Muncher, Vered Yahalom, Nicole M. Thornton   +7 more
wiley   +1 more source

TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

The Interaction of Papain with Polycations

, 1989
An investigation has been made of the interactions of the enzyme papain with the polycations protamine, polybrene, poly(L-lysine), spermine, spermidine and the neutral polymer polyvinylpyrrolidone (PVP).
J B Lawton, R J Washington, C I Mekras
core   +1 more source

Stac2 genetic deletion alters mouse chromaffin cells’ CaV channel composition, increases membrane excitability and reduces vesicle exocytosis

The Journal of Physiology, EarlyView.
Abstract figure legend Stac2 adaptor protein is expressed in neurons and endocrine cells. Using a global Stac2 knockout mouse model here we investigated the role of endogenous Stac2 in adrenal gland mouse chromaffin cell (MCC) excitability and catecholamine vesicle exocytosis.
Stefanie M. Geisler, Noelia Jacobo‐Piqueras, Tamara Theiner, Ryoichi S. Taguchi, Laura E. Häfele, Marta Campiglio, Petronel Tuluc   +6 more
wiley   +1 more source

Investigation of crosslinked hydrogel comprising papain for lesion recovery acceleration [PDF]

11 p.Papain is a common protease exhibiting antioxidant and anti-inflammatory activities. Papain can be extracted from seeds, leaves or latex of papaya (Carica papaya L.). It is involved in accelerating wound healing process. Hydrogels are widely used in
Nguyen, Ngoc Sao Mai
core   +2 more sources

Effect of Dietary Papaya (Carica papaya) Leaf Meal on Growth Performance and Haematological Responses of Nile Tilapia (Oreochromis niloticus) Fingerlings Reared in a Recirculating Aquaculture System [PDF]

Vet Med Sci
The study examined the efficacy of papaya leaf meal as a growth promoter of Nile tilapia fingerling. Certain level (9%) of papaya leaf meal in diet can improve the weight gain, SGR, PER and FCR of fish. It can also enhance the haematological parameters such as RBC, WBC and haemoglobin content of tilapia fingerling.
Farhad F, Ritu F, Mustafi M, Salam M, Hashem S.   +4 more
europepmc   +2 more sources