Results 141 to 150 of about 51,553 (242)

Papain and related proteins [PDF]

Nature, 1990
openaire   +2 more sources

A food-grade cell dissociation agent via regulatory pre-check framework. [PDF]

PLoS One
Hatano H, Sawada M, Kitsukawa M, Hayakawa A, Kondo H, Kawashima I.   +5 more
europepmc   +1 more source

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation

Aging Cell, Volume 25, Issue 6, June 2026.
Tetracyclines extend lifespan and protect neurons from ferroptosis by attenuating protein synthesis across multiple eukaryotic models through ISR‐dependent or ISR‐independent mechanisms, enabling classification based on their mode of action. ABSTRACT Reducing protein synthesis extends lifespan across taxa, but pharmacological strategies to safely ...
Khalyd J. Clay, Manuel Sanchez‐Alavez, Ian Newman, Na Na, Ana P. Verduzco Espinoza, Alan To, Shannon Saad, Hollis T. Cline, Michael Petrascheck   +8 more
wiley   +1 more source

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice. [PDF]

Acta Neuropathol
Mignolet M, Deroux C, Florkin T, Bielarz V, De Swert K, Halloin N, Sprimont L, Ladang A, George F, Gilloteaux J, Abeloos L, Garin P, Van Weyenbergh J, Jamoulle M, Diederich C, Gillet NA, Bulpa P, Nicaise C.   +17 more
europepmc   +1 more source

The Sulfur Distribution of Papain

Journal of Biological Chemistry, 1965
A N, GLAZER, E L, SMITH
openaire   +2 more sources

TTX‐S/TTX‐R Na+ Currents Coordinately Fine‐Tune Depolarization/Firing Capability Revealed by Voltage Derivatives/Displacement Current Phase Plots With Dynamic Current‐Clamp Simulation in Rat Visceral Sensory Neurons

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim To investigate how tetrodotoxin‐sensitive (TTX‐S) and tetrodotoxin‐resistant (TTX‐R) Na+ channels coordinately fine‐tune action potential (AP) depolarization and firing capability in rat nodose visceral sensory neurons. Methods APs were recorded by ruptured‐patch current clamp in unmyelinated C‐type and myelinated Ah‐type neurons from ...
Zhang Jing‐ran, Fu Hui‐xiao, Li Xing‐yu, Zhang Hong‐fei, Dou Tian‐min, Li Bai‐yan, Wu Di   +6 more
wiley   +1 more source

Digital PCR-based characterization of certified genomic DNA reference materials from genetically modified papaya Huanong No. 1. [PDF]

BMC Biotechnol
Yang G, Pan Z, Zheng S, He G, Zhu L, Wu C, Yao J, Li L, Jiang D.   +8 more
europepmc   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

The application of digital PCR to characterize genomic DNA certified reference materials of genetically modified papaya YK1601. [PDF]

GM Crops Food
He G, Pan Z, Zhou J, He Y, Yang G, Zhu L, Yao J, Jiang D.   +7 more
europepmc   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source