Results 141 to 150 of about 63,884 (240)
Aging Cell, Volume 25, Issue 11, November 2026.FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 21, Page 6501-6518, November 2026.Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca +4 more
wiley +1 more source
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
Erosion Potential of Commercial Fluoride‐Free Mouthwashes on Dental Hard Tissues
International Journal of Dental Hygiene, Volume 24, Issue 4, Page 658-667, November 2026.ABSTRACT Purpose Mouthwashes often present acidic pH, which raises concerns about their potential contribution to erosive tooth wear. This study evaluated the erosive potential of commercial fluoride‐free mouthwashes using a screening method.
Astrid C. Valdivia‐Tapia +5 more
wiley +1 more source
Synergistic Alcalase-papain hydrolysis of egg white protein: enhancing structural unfolding, antioxidant activity, and gastrointestinal stability. [PDF]
Food Chem XShi J, Li X, Song X, Wang S.
europepmc +1 more source
, 2011 Enzymes are proteins that can increase the rate of biological changes, such as the ripening of fruit. Papain enzyme is obtained from the green papaya (pawpaw)
Practical Action
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The Mechanism of Whey Protein Hydrolysates with Oral Immunotolerance. [PDF]
Int J Mol SciWang MY, An PM, Mao L, Zhao WX, Cong YJ.
europepmc +1 more source
IL-1R1-MyD88 axis elicits early papain-induced lung inflammation
, 2015 Allergic asthma is characterized by a strong Th2 response with inflammatory cell recruitment and structural changes in the lung. Papain is a protease allergen disrupting the airway epithelium triggering a rapid inflammation with eosinophilia mediated by ...
Di Padova, Franco E., Mueller, Matthias
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Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano +3 more
wiley +1 more source
Exploring the protease inhibitory potential of 2-bromo-2-nitro-1,3- propanediol (Bronopol): Initial findings. [PDF]
Biochem Biophys RepJiang C, Krzyzanowski G, Fernando MR.
europepmc +1 more source