Results 151 to 160 of about 63,884 (240)

Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Six nitrile‐based covalent inhibitors are evaluated against cruzain and hCatL. Thermodynamic integration accurately predicts relative binding affinities by modeling the covalent adduct state. We identify a structural difference in the S2 subsite that governs ligand selectivity, offering valuable insights for drug discovery.
Yan Carvalho Magno, Luiz Fernando Barbosa, Maycon Vinicius Damasceno de Oliveira, Jerônimo Lameira, Carlos A. Montanari   +4 more
wiley   +1 more source

Fluorescence Turn-Off Sensing of Protease Activity with Carbon Dots: Papain as a Model System for Surface Accessibility-Driven Interfacial Kinetics. [PDF]

ACS Omega
Phunswat W, Suwanchawalit C, Sirasunthorn N.   +2 more
europepmc   +1 more source

Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling. [PDF]

JCI Insight
Wu H, Tao R, Xie S, Zhou Y, Xu JF, Xia Z, Su X.   +6 more
europepmc   +1 more source

Papain- and Trypsin-Derived Spirulina Peptides: Antiproliferative and Antioxidant Profiles. [PDF]

J Food Sci
Hassan SN, Ghafoor DD.
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Gel Filtration Chromatography-Guided Sequential Hydrolysis of <i>Sthenoteuthis</i><i>oualaniensis</i> Protein: Peptide Distribution and Functional Properties. [PDF]

Foods
Yao Q, Wang H, Yang H, Hong R, Zhong Y, Diao X, Wu W.   +6 more
europepmc   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, Volume 13, Issue 56, 9 October 2026.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Baicalein Attenuates Eosinophilic Rhinosinusitis by Suppressing ALOX15-Mediated M2 Macrophage Function. [PDF]

Int J Mol Sci
Wang L, Zhu Z, Liu Y, Aodeng S, Kang T, Wang W, Lv W.   +6 more
europepmc   +1 more source

Gut Microbial Release of Ferulic Acid From Germinated Quinoa Alleviates Obesity‐Associated Cognitive Impairment by Activating Hippocampal Mitophagy Associated with PINK1/Parkin Pathway

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Liberation of ferulic acid by gut microbial feruloyl esterase mediates cognitive enhancement of germinated quinoa (GQF) on obese mice. Ferulic acid enriched in GQF is released by gut microbes Roseburia hominis and R. intestinalis and subsequently mediates the neuroprotective effects of GQF on obesity‐induced cognitive decline by activating hippocampal ...
Yongli Lan, Wengang Zhang, Lei Wang, Shiyang Zhao, Yujie Song, Xinze Wang, Yutang Wang, Xijuan Yang, Shaobo Ma, Junlin Ge, Rui Guo, Xuebo Liu   +11 more
wiley   +1 more source

Low-temperature preparation of enzyme-treated sesame paste: Quality enhancement and hazard mitigation. [PDF]

Food Chem X
Jin L, Ma YX, Hou LX, Wang XD, Yang JC, Xu YM, Liu HM.   +6 more
europepmc   +1 more source