Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin [PDF]
, 1985 In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cytotoxic ...
Feijen, J. +6 more
core +2 more sources
Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]
, 2016 Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K. +4 more
core +4 more sources
In vitro and in vivo anthelmintic efficacy of plant cysteine proteinases against the rodent gastrointestinal nematode, Trichuris muris [PDF]
, 2006 We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig, kiwi fruit and Egyptian milkweed in vitro using the rodent gastrointestinal nematode Heligmosomoides polygyrus.
Behnke, J.M. +4 more
core +3 more sources
Jurnal Kimia Valensi, 2012 Telah dilakukan penelitian tentang pengaruh ekstrak rokok, kopi dan minuman beralkohol terhadap aktivitas enzim papain. Tujuan penelitian ini untuk mengetahui pengaruh ekstrak rokok, kopi dan minuman beralkohol terhadap aktivitas enzim pencernaan ...
La Ode Sumarlin +2 more
doaj +1 more source
Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo [PDF]
, 2007 Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, H eligmosomoides polygyrus (which is found in
Behnke, J.M. +4 more
core +3 more sources
Solution structure of a phytocystatin from Ananas comosus and its molecular interaction with papain. [PDF]
PLoS ONE, 2012 The structure of a recombinant pineapple cystatin (AcCYS) was determined by NMR with the RMSD of backbone and heavy atoms of twenty lowest energy structures of 0.56 and 1.11 Å, respectively.
Deli Irene +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Papain is a proteolytic enzyme present in the leaves, fruits, roots, and latex of the Carica papaya (papaya) plant. Although it exhibits a wide range of activities, there are no reports on the anti-obesity effects of papain.
Yun-Mi Kang +4 more
semanticscholar +1 more source
Allergology International, 2014 Background: Epicutaneous sensitization to allergens is important in the pathogenesis of not only skin inflammation such as atopic dermatitis but also "atopic march" in allergic diseases such as asthma and food allergies.
Hideo Iida +10 more
doaj +1 more source
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]
, 2017 MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark +7 more
core +2 more sources
Effect of different combinations of papain-based gels on dissolving pulp tissue
Bioscience Journal, 2017 The focus of this study was to evaluate the capacity to dissolve pulp tissue of various combinations of papain-based gels and other antimicrobial agents.
Matheus Melo Pithon +6 more
doaj +3 more sources