Results 31 to 40 of about 51,553 (242)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Hydrolysis of Soybean Milk Protein by Papain: Antioxidant, Anti-Angiotensin, Antigenic and Digestibility Perspectives

Bioengineering, 2022
The objective of the investigation was to understand the biochemical activities of hydrolysate of soybean milk protein (SMP). Hydrolysis was carried out by different concentrations of papain (0.008 g·L−1, 0.016 g·L−1, 0.032 g·L−1 and 0.064 g·L−1).
Arijit Nath, Abubakar Saleh Ahmad, Abraham Amankwaa, Barbara Csehi, Zsuzsanna Mednyánszky, Emőke Szerdahelyi, Attila Tóth, Judit Tormási, Duy Hoàng Truong, László Abrankó, András Koris   +10 more
doaj   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Pengaruh Dosis Enzim Papain terhadap Rendemen dan Kualitas Virgin Coconut Oil (VCO)

Jurnal Agro Industri Perkebunan, 2015
Virgin Coconut Oil (VCO) is the coconut oil that is produced naturally without chemicals and heating process. Papain enzyme is a protease that is used in the fermentation of milk serves as a catalyst in the manufacture of the VCO.
Ahmat Iskandar, Ersan Ersan, Rachmad Edison   +2 more
doaj   +1 more source

Current-Volt Biosensing “Cystatin C” on Carbon Nanowired Interdigitated Electrode Surface: A Clinical Marker Analysis for Bulged Aorta

Journal of Analytical Methods in Chemistry, 2022
A carbon nanowire-modified surface with interdigitated electrode (IDE) sensing system was introduced to identify abdominal aortic aneurysm biomarker “papain,” also known as cysteine protease, used as the capture probe to identify Cystatin C.
Xi Chen, Jie Kang, Qiu Sun, Cheng Liu, Hongling Wang, Chen Wang, Subash C. B. Gopinath   +6 more
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

c-Rel Is Required for IL-33-Dependent Activation of ILC2s

Frontiers in Immunology, 2021
Group 2 innate lymphoid cells (ILC2s) are emerging as important cellular regulators of homeostatic and disease-associated immune processes. The cytokine interleukin-33 (IL-33) promotes ILC2-dependent inflammation and immunity, with IL-33 having been ...
Aidil Zaini, Aidil Zaini, Thomas S. Fulford, Raelene J. Grumont, Raelene J. Grumont, Jessica Runting, Jessica Runting, Grace Rodrigues, Grace Rodrigues, Judy Ng, Judy Ng, Steve Gerondakis, Steve Gerondakis, Colby Zaph, Colby Zaph, Sebastian Scheer, Sebastian Scheer   +16 more
doaj   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

LAMA PEMBERSIHAN EFISIEN PAPAIN PADA PENGLEPASAN PLAK GIGITIRUAN

Journal of Dentistry Indonesia, 2015
Everyday denture cleaning is needed to prevent the mouth from denture stomatitis and esthetic concern. Enzyme cleansers are developed in attempt to break down the organic components of denture plaque.
Siti Sunarintyas
doaj   +1 more source

In Search of Antioxidant Peptides from Porcine Liver Hydrolysates Using Analytical and Peptidomic Approach

Antioxidants, 2021
The search for antioxidant peptides as health-promoting agents is of great scientific interest for their biotechnological applications. Thus, the main goal of this study was to identify antioxidant peptides from pork liver using alcalase, bromelain ...
María López-Pedrouso, José M. Lorenzo, Paula Borrajo, Daniel Franco   +3 more
doaj   +1 more source