Results 11 to 20 of about 108,628 (305)

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease

Journal of Medicinal Chemistry, 2022
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines and small-molecule antivirals is vital in combating the pandemic.
Hao Tan, Yanmei Hu, Prakash A. Jadhav, Bin Tan, Jun Wang   +4 more
semanticscholar   +1 more source

Identification and classification of papain-like cysteine proteinases

Journal of Biological Chemistry, 2023
Papain-like cysteine peptidases form a big and highly diverse superfamily of proteins involved in many important biological functions, such as protein turnover, deubiquitination, tissue remodeling, blood clotting, virulence, defense, and cell wall ...
Fatih Ozhelvaci, Kamil Steczkiewicz
semanticscholar   +1 more source

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Nature, 2020
The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread 1 , 2 .
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, D. Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, M. Widera, A. Mehdipour, G. Tascher, P. Geurink, A. Wilhelm, Gerbrand J. van der Heden van Noort, H. Ovaa, S. Müller, K. Knobeloch, K. Rajalingam, B. Schulman, J. Cinatl, G. Hummer, S. Ciesek, I. Dikič   +21 more
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Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Nature Communications, 2020
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals.
J. Osipiuk, S. Azizi, Steve Dvorkin, M. Endres, R. Jedrzejczak, Krysten A. Jones, Soowon Kang, R. Kathayat, Youngchang Kim, V. Lisnyak, S. Maki, V. Nicolaescu, Cooper A. Taylor, C. Tesar, Yu-an Zhang, Zhiyao Zhou, G. Randall, K. Michalska, S. Snyder, B. Dickinson, A. Joachimiak   +20 more
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SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition

ChemBioChem, 2022
Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets.
S. Ullrich, Christoph Nitsche
semanticscholar   +1 more source

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Science Advances, 2020
A multidisciplinary approach yields novel inhibitors and reveals substrate specificity, structure, and mechanisms of CoV-2 PLpro. Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target ...
Wioletta Rut, Z. Lv, Mikołaj Żmudziński, Stephanie Patchett, D. Nayak, S. Snipas, Farid El Oualid, Tony T. Huang, M. Békés, M. Drąg, S. Olsen   +10 more
semanticscholar   +1 more source

Immobilization of papain: A review.

International Journal of Biological Macromolecules, 2021
Papain is a cysteine protease from papaya, with many applications due to its broad specificity. This paper reviews for first time the immobilization of papain on different supports (organic, inorganic or hybrid supports) presenting some of the features ...
Veymar G. Tacias-Pascacio, Roberto Morellon-Sterling, D. Castañeda-Valbuena, Á. Berenguer-Murcia, M. Kamli, O. Tavano, R. Fernández-Lafuente   +6 more
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Bioactive peptides from fisheries residues: A review of use of papain in proteolysis reactions.

International Journal of Biological Macromolecules, 2021
Papain is a cysteine endopeptidase of vegetal origin (papaya (Carica papaya L.) with diverse applications in food technology. In this review we have focused our attention on its application in the production of bio-peptides by hydrolysis of proteins from
Veymar G. Tacias-Pascacio, D. Castañeda-Valbuena, Roberto Morellon-Sterling, O. Tavano, Á. Berenguer-Murcia, G. Vela-Gutiérrez, I. Rather, R. Fernández-Lafuente   +7 more
semanticscholar   +1 more source

Crystal structure of SARS-CoV-2 papain-like protease

Acta Pharmaceutica Sinica B, 2020
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine.
Xiaopan Gao, B. Qin, Pu Chen, K. Zhu, P. Hou, J. Wojdyla, Meitian Wang, S. Cui   +7 more
semanticscholar   +1 more source

In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies

Molecules, 2021
Papain-like protease is an essential enzyme in the proteolytic processing required for the replication of SARS-CoV-2. Accordingly, such an enzyme is an important target for the development of anti-SARS-CoV-2 agents which may reduce the mortality ...
Mohamed S. Alesawy, E. Elkaeed, Aisha A. Alsfouk, A. Metwaly, I. Eissa   +4 more
semanticscholar   +1 more source