Results 111 to 120 of about 16,162 (223)

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase

, 2019
Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular ...
Kalejta, Robert F., Hume, Adam J., Kamil, Jeremy P., Münger, Karl, Jurak, Igor, Coen, Donald M.   +5 more
core   +1 more source

E6/E7 and E6* From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes

Frontiers in Immunology, 2019
Keratinocyte infection with high-risk human papillomavirus genotypes has been linked to cancer development. In cervix, the alpha HPV16 and HPV18 have been reported as the mayor causative agents of cervical cancer.
Cristina Artaza-Irigaray, Andrea Molina-Pineda, Andrea Molina-Pineda, Adriana Aguilar-Lemarroy, Pablo Ortiz-Lazareno, Laura P. Limón-Toledo, Ana L. Pereira-Suárez, Wendoline Rojo-Contreras, Luis F. Jave-Suárez   +8 more
doaj   +1 more source

Cellular immune responses to human papillomavirus (HPV) type 16 at the cervix of women with HPV-associated squamous intraepithelial neoplasia

, 2005
Includes bibliographical references.Cervical cancer is the most common cause of cancer-related death in black South African women. Human papillomavirus (HPV) has been found to be a necessary causative agent of cervical cancer and has been reported to be ...
Milner, Michelle
core  

The HPV-18 E7 CKII phospho acceptor site is required for maintaining the transformed phenotype of cervical tumour-derived cells.

PLoS Pathogens, 2019
The Human Papillomavirus E7 oncoprotein plays an essential role in the development and maintenance of malignancy, which it achieves through targeting a number of critical cell control pathways.
Om Basukala, Suruchi Mittal, Paola Massimi, Marco Bestagno, Lawrence Banks   +4 more
doaj   +1 more source

The Relative Ability of Human Papillomavirus Type 6 and Human Papillomavirus Type 16 E7 Proteins to Transactivate E2F-Responsive Elements Is Promoter- and Cell-Dependent

, 1997
The human papillomavirus 16 E7 protein (HPV 16 E7) transactivates the adenovirus E2 promoter (AdE2) by altering interactions between retinoblastoma (pRb) family members and the transcription factor E2F.
Armstrong, Deborah J., Roman, Ann
core   +1 more source

Human papillomavirus E7 protein induces homologous recombination defects and PARPi sensitivity

Journal of Cancer Research and Clinical Oncology
Abstract Purpose Cervical cancer is a common gynecological malignancy, pathologically associated with persistent infection of high-risk types of human papillomavirus (HPV). Previous studies revealed that HPV-positive cervical cancer displays genomic instability; however, the underlying mechanism is not fully understood.
He, Siqi, Wang, Ao, Wang, Jing, Tang, Zizhi, Wang, Xiaojun, Wang, Danqing, Chen, Jie, Liu, Cong, Zhao, Mingcai, Chen, Hui, Song, Liang   +10 more
openaire   +2 more sources

Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants

, 1992
Functional analysis of human papillomavirus type 16 E7 protein by complementation with adenovirus E1A mutants in baby rat kidney cells has shown that the retinoblastoma gene product (RB)-binding region of E7 can substitute in trans for that of E1A.
Vousden, K H, Davies, R C
core   +1 more source

The effect of phosphorylation efficiency on the oncogenic properties of the protein E7 from high-risk HPV

Virus Research
The Human papillomavirus (HPV) causes tumors in part by hijacking the host cell cycle and forcing uncontrolled cellular division. While there are >200 genotypes of HPV, 15 are classified as high-risk and have been shown to transform infected cells and ...
Madison Malone, Ava Maeyama, Naomi Ogden, Kayla N. Perry, Andrew Kramer, Caleb Bates, Camryn Marble, Ryan Orlando, Amy Rausch, Caleb Smeraldi, Connor Lowey, Bronson Fees, H. Jane Dyson, Michael Dorrell, Heidi Kast-Woelbern, Ariane L. Jansma   +15 more
doaj   +1 more source

Human Papillomavirus Type 16 E6 and E7 Cause Polyploidy in Human Keratinocytes and Up-Regulation of G2-M-phase Proteins

, 2004
Human papillomavirus type 16 proteins E6 and E7 have been shown to cause centrosome amplification and lagging chromosomes during mitosis. These abnormalities during mitosis can result in missegregation of the chromosomes, leading to chromosomal ...
Wang, N., Incassati, A., Patel, Daksha, McCance, Dennis   +3 more
core   +1 more source

What are the essential determinants of human papillomavirus carcinogenesis?

mBio
Human papillomavirus (HPV) infection is the leading viral cause of cancer. Over the past several decades, research on HPVs has provided remarkable insight into human cell biology and into the pathology of viral and non-viral cancers.
Karl Munger, Elizabeth A. White
doaj   +1 more source