Results 101 to 110 of about 16,162 (223)

HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

BMC Cancer, 2018
Background Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype.
Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia, Luisa Lina Villa   +6 more
doaj   +1 more source

Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product

Journal of General Virology, 1993
Binding of the human papillomavirus type 16 (HPV-16) E7 oncoprotein to the retinoblastoma protein (pRb) is thought to be involved in the cellular transformation mediated by HPV-16. Here we show that the E7 protein of the cottontail rabbit papillomavirus (CRPV) binds to the same C-terminal portion of human pRb as HPV-16 E7, and that both the CRPV and ...
K M, Haskell, G A, Vuocolo, D, Defeo-Jones, R E, Jones, M, Ivey-Hoyle   +4 more
openaire   +2 more sources

Sublineage‐Specific A45S Polymorphism Alters the Biological Function of the Human Papillomavirus 11 E7 Protein

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT The E7 oncoprotein of human papillomavirus (HPV) plays a crucial role in viral pathogenesis and replication. Although it is generally highly conserved across HPV genotypes, naturally occurring E7 variants can display functional differences that may affect viral persistence, oncogenic potential, and host cellular responses.
Zsolt Barnabás Éles, Leila Rahmani, Eszter Gyöngyösi, Krisztina Szarka, István Rebenku, György Veress, Tamás Major, József Kónya, Anita Szalmás   +8 more
wiley   +1 more source

HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14

mBio
High-risk human papillomavirus (HPV) oncoproteins inactivate cellular tumor suppressors to reprogram host cell signaling pathways. HPV E7 proteins bind and degrade the tumor suppressor PTPN14, thereby promoting the nuclear localization of the YAP1 ...
William J. Blakely, Joshua Hatterschide, Elizabeth A. White   +2 more
doaj   +1 more source

Immunohistochemistry for p16 and p53 Provides Substantial Agreement With Molecular Tests in Penile Cancer

Pathology International, Volume 76, Issue 6, June 2026.
In penile squamous cell carcinoma, p16 and p53 immunohistochemistry showed substantial concordance with molecular testing (Cohen's kappa 0.6–0.7). Aberrant p53 expression profiles (overexpression or null phenotype) were associated with significantly worse survival.
Jan Hrudka, Jan Hojný, Eva Krkavcová, Jiří Dvořák, Zuzana Prouzová, Michaela Kendall Bártů, Nicolette Zavillová, David Čapka, Radoslav Matěj, Petr Waldauf   +9 more
wiley   +1 more source

The role of human papillomavirus (HPV) E6 proteins as a risk factor for oesophageal cancer

, 2007
Includes bibliographical references (leaves 74-83).Oesophageal squamous cell carcinoma (OSCC) is a major cancer in South Africa, affecting mainly black males.
Ross-Innes, Caryn Sarah
core  

The role and mechanism of human papillomavirus in urinary system tumors

Journal of International Medical Research
Based on the level of carcinogenic risk, human papillomavirus can be categorized into high-risk and low-risk types. High-risk human papillomavirus (such as human papillomavirus 16 and human papillomavirus 18) induces the inactivation of tumor suppressor ...
Hongxia Huang, Shubing Feng, Yuanhang Liu   +2 more
doaj   +1 more source

Detection of human papillomavirus (HPV) and expression of cell-cycle markers in breast carcinoma in a cohort of South African patients

, 2013
Includes abstract.Includes bibliographical references.Breast carcinoma is a common cancer in South African women. In the Republic of South Africa, 41 new cases of breast cancer are diagnosed per 100 000 population and the mortality rate is 21 per 100 000
Fenwick, Sharon
core  

Human Papillomavirus E7 oncoprotein increases production of the anti-inflammatory IL-18 binding protein (IL-18BP) in keratinocytes [PDF]

, 2014
Human papillomavirus can successfully evade the host immune response to establish a persistent infection. We show here that expression of the E7 oncoprotein in primary human keratinocytes results in increased production of IL-18 binding protein (IL-18BP).
Doble, R, Wasson, CW, Richards, KH, Wittmann, M, Blair, GE, Macdonald, A, Haider, M   +6 more
core   +1 more source

Recombinant adenoviruses expressing HPV16/18 E7 upregulate the HDAC6 and DNMT3B genes in C33A cells

Frontiers in Cellular and Infection Microbiology
ObjectiveHigh-risk human papillomavirus (HPV) is a carcinogenic virus associated with nearly all cases of cervical cancer, as well as an increasing number of anal and oral cancers.
Yunting Shao, Pir Tariq Shah, Qisheng Su, Shanhu Li, Fang Huang, Jun Wang, Peng Wang, Chengjun Wu   +7 more
doaj   +1 more source