Results 91 to 100 of about 16,162 (223)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Persistent infection with high‐risk human papillomavirus (HR‐HPV) is defined as the principal cause of cervical cancer. Given the important role of cervicovaginal microbiota in HPV acquisition and disease progression, this study aims to evaluate the clinical efficacy of the probiotic Enterococcus faecium (E.
Jun Yang +6 more
wiley +1 more source
Low- and high-risk human papillomavirus E7 proteins regulate p130 differently
Virology, 2010 The E7 protein of high-risk human papillomaviruses (HR HPVs) targets pRb family members (pRb, p107 and p130) for degradation; low-risk (LR) HPV E7 only targets p130 for degradation. The effect of HR HPV 16 E7 and LR HPV 6 E7 on p130 intracellular localization and half-life was examined.
Barrow-Laing, Lisa +2 more
openaire +2 more sources
Cell cycle control and its modulation in HPV infected cells
, 2010 A key effect of human papillomavirus (HPV) infection is to disrupt the normal cell cycle in order to subvert the cellular DNA replication machinery. Morphologically, condylomata induced by high and low risk HPV types cannot be distinguished and many ...
Lyman, Rachel C.
core
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: Human papillomavirus (HPV) is one of the infectious agents that causes genital and non-genital warts and skin cancers in humans.
Tahoora Mousavi +3 more
doaj
Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens
, 2019 Many of the small DNA tumor viruses encode transforming proteins that function by targeting critical cellular pathways involved in cell proliferation and survival.
White, Elizabeth +9 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2017 Toxicity and resistance remain major challenges for advanced or recurrent cervical cancer therapies, as treatment requires high doses of chemotherapeutic agents.
Nirmal Rajasekaran +9 more
doaj +1 more source
International Journal of Cancer, Volume 158, Issue 11, Page 3021-3037, 1 June 2026.What's new? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies +12 more
wiley +1 more source
Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines
, 2011 Includes abstract.Includes bibliographical references (leaves 153-175).Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical ...
Pineo, Catherine
core
Dimerization of the Human Papillomavirus E7 Oncoproteinin Vivo
, 1995 We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexesin vivo.The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also ...
BRENT, ROGER +3 more
core +1 more source