Results 101 to 110 of about 666,834 (274)

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis. [PDF]

, 2019
The gastrointestinal (GI) tract can play a critical role in the development of pathologies associated with overeating, overweight and obesity. We previously observed that supplementation with anthocyanins (AC) (particularly glycosides of cyanidin and ...
Adamo, Ana M, Cremonini, Eleonora, Daveri, Elena, Fraga, Cesar G, Hester, Shelly N, Kalanetra, Karen, Mastaloudis, Angela, Mills, David, Oteiza, Patricia I, Wood, Steve M   +9 more
core   +2 more sources

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

Science Translational Medicine, 2018
Tenapanor inhibits sodium/hydrogen exchanger isoform 3 to reduce intestinal phosphate absorption via reduction of passive paracellular phosphate flux. Phosphate in flux Kidney failure can decrease the excretion of phosphate, leading to elevated phosphate
A. King, Matthew Siegel, Ying He, Baoming Nie, Ji Wang, S. Koo-McCoy, N. Minassian, Qumber Jafri, D. Pan, Jill Kohler, Padmapriya Kumaraswamy, K. Kozuka, J. G. Lewis, D. Dragoli, D. Rosenbaum, D. O'Neill, Allein Plain, P. Greasley, A. Jönsson-Rylander, D. Karlsson, Margareta Behrendt, M. Strömstedt, T. Rydén-Bergsten, T. Knöpfel, E. M. Pastor Arroyo, N. Hernando, J. Marks, M. Donowitz, C. Wagner, R. T. Alexander, J. Caldwell   +30 more
semanticscholar   +1 more source

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins [PDF]

Proceedings of the National Academy of Sciences, 2004
Mutations in the WNK4 gene cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder of hyperkalemia and hypertension. The target molecules of this putative kinase and the molecular mechanisms by which the mutations cause the phenotypes are currently unknown. Although recent reports found that expression of WNK4 in
Kozue, Yamauchi, Tatemitsu, Rai, Katsuki, Kobayashi, Eisei, Sohara, Tatsunori, Suzuki, Tomohiro, Itoh, Shin, Suda, Atsushi, Hayama, Sei, Sasaki, Shinichi, Uchida   +9 more
openaire   +2 more sources

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Ali, Bae, Baker, Baker, Barker, Bartlett, Brennan, Bubeck Wardenburg, Coyne, Dasenbrook, Deborah L Baines, Emma H Baker, Forrest, Garnett, Garnett, Garnett, Gwenan M Knight, Hallows, Hundal, James P Garnett, Jodi A Lindsay, John S Tregoning, Kalsi, Kalsi, Kapetanovic, Kennedy, Kupeli, Merlo, Myerburg, O'Neill, Peng, Pezzulo, Philips, Philips, Phillips, Radwan, Sakar, Saumon, Shore, Simren Gill, Sonam Naik, Sum, Tamer, Walker, Wood, Wu, Zhang, Zhang   +47 more
core   +1 more source

Paracellular and transcellular pathways facilitate insulin permeability in rat gut

Journal of Pharmacy and Pharmacology, 2006
AbstractThe aim of this study was to conduct a systematic investigation of the absorption of insulin in the rat intestine in the presence of permeation enhancers and protease inhibitors. An in-situ perfused rat gut model was used for the co-perfusion of insulin and PEG 4000 in the presence or absence of bile salts, bile salt:fatty acid surfactant ...
Majella E, Lane, Owen I, Corrigan
openaire   +2 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]

, 2016
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source