Results 81 to 90 of about 328,971 (180)

Reversibly unlocking the blood–brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide

Acta Pharmaceutica Sinica B
The blood–brain barrier (BBB) is a crucial biological interface between the central nervous system and circulation, playing a key role in maintaining the brain's homeostasis and function, but presenting a challenge for drug delivery.
Junrong Wu, Guangman Cui, Zhousheng Lin, Wanmei Lin, Yaqing Zhang, Tianhang Zhou, Ping He, Yunjiao Zhang, Guangyu Yao   +8 more
doaj   +1 more source

Blood-brain barrier tight junction permeability and ischemic stroke

Neurobiology of Disease, 2008
The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels, providing a dynamic interface between the peripheral circulation and the central nervous system.
Karin E. Sandoval, Ken A. Witt
doaj   +1 more source

Probing the Action of Permeation Enhancers Sodium Cholate and N-dodecyl-β-D-maltoside in a Porcine Jejunal Mucosal Explant System

Pharmaceutics, 2018
The small intestinal epithelium constitutes a major permeability barrier for the oral administration of therapeutic drugs with poor bioavailability, and permeation enhancers (PEs) are required to increase the paracellular and/or transcellular uptake of ...
E. Michael Danielsen, Gert H. Hansen
doaj   +1 more source

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

, 2012
In the kidney, tight junction proteins contribute to segment specific selectivity and permeability of paracellular ion transport. In the thick ascending limb (TAL) of Henle's loop, chloride is reabsorbed transcellularly, whereas sodium reabsorption takes
Stuiver, M., Willnow, T.E., Himmerkus, N., Mueller, D., Will, C., Breiderhoff, T., Bleich, M., Bachmann, S., Meij, I.C., Mutig, K.   +9 more
core   +1 more source

Changes in Colonic Paracellular Permeability Are Associated with Airway Challenge in Ovalbumin Sensitized Mice

, 2004
Changes in Colonic Paracellular Permeability Are Associated with Airway Challenge in Ovalbumin Sensitized Mice.
Tondereau, Valérie, Fioramonti, Jean, Cenac, Nicolas, Eutamène, Hélène, Garcia Villar, Rafael, Theodorou, Vassilia, Bueno, Lionel   +6 more
core   +3 more sources

Cisplatin, rather than oxaliplatin, increases paracellular permeability of LLC-PK1 cells via activating protein kinase C [PDF]

, 2019
The clinical use of cisplatin is limited by its adverse events, particularly serious nephrotoxicity. It was clarified that cisplatin is transported by a kidney-specific organic cation transporter (OCT2).
Zhang, Yunpeng, Nakagawa, Takayuki, Yonezawa, Atsushi, Imai, Satoshi, Denda, Masaya, Matsubara, Kazuo, Nakagawa, Shunsaku, Omura, Tomohiro   +7 more
core   +1 more source

Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability alterations induced by irritable bowel syndrome mediators

Gut Microbes
Irritable bowel syndrome (IBS) is a multifactorial condition with heterogeneous pathophysiology, including intestinal permeability alterations.
Maria Raffaella Barbaro, Francesca Bianco, Cesare Cremon, Giovanni Marasco, Francesca Bonomini, Marta Palombo, Cecilia Delprete, Marta Perez, Jordi Espadaler-Mazo, Vincenzo Stanghellini, Simone Guglielmetti, Giovanni Barbara   +11 more
doaj   +1 more source

Regulation of blood vascular permeability in the skin

Inflammation and Regeneration, 2017
Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines, amyloids, lipoproteins, carrier proteins ...
Sachiko Ono, Gyohei Egawa, Kenji Kabashima   +2 more
doaj   +1 more source

Acamprosate permeability across Caco-2 cell monolayer is predominantly paracellular

, 2018
Background. The human oral bioavailability (BA) of acamprosate is 11% and its oral absorption is permeability limited (BCS class III). Acamprosate is not metabolized, therefore it’s BA has the same nominal value as its fraction absorbed (fa).
Neuhoff, Sibylle, Fretté, Xavier; id_orcid, Nielsen, Carsten Uhd; id_orcid, Steffansen, Bente, Antonescu, Irina-Elena   +4 more
core  

CAR modulates E-cadherin dynamics in the presence of adenovirus type 5.

PLoS ONE, 2011
Adenovirus (Ad) serotype 5 (Ad5) fiber competitively binds to the coxsackievirus and Ad receptor (CAR) to attach Ad5 to target cells and also disrupts cell junctions and facilitates virus escape at a late stage in Ad5 infection.
Fawziyah Hussain, Penny E Morton, Marjolein Snippe, Janis Sullivan, Charlotte Farmer, Marisa L Martin-Fernandez, Maddy Parsons, George Santis   +7 more
doaj   +1 more source