Results 81 to 90 of about 41,666 (255)

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Brush border membrane vesicle and Caco-2 cell line: Two experimental models for evaluation of absorption enhancing effects of saponins, bile salts, and some synthetic surfactants

Journal of Advanced Pharmaceutical Technology & Research, 2016
The aim of this study was to investigate the influence of absorption enhancers in the uptake of hydrophilic compounds. The permeation of the two hydrophilic drug models gentamicin and 5 (6)-carboxyfluorescein (CF) across the brush border membrane ...
Eskandar Moghimipour, Sayyed Abolghassem Sajadi Tabassi, Mohammad Ramezani, Somayeh Handali, Raimar Lobenberg   +4 more
doaj   +1 more source

An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence

Scientific Reports, 2023
Acyclovir, an antiviral drug, has low bioavailability due to its low permeability. Consequently, high drug doses and frequent administration are required.
Omar Y. Mady, Sara Mohsen Thabit, Suzan E. Abo Elnasr, Asmaa A. Hedaya   +3 more
doaj   +1 more source

Do We Have a Proper Model? [PDF]

, 2014
It has been reported recently that the cystic fibrosis transmembrane conductance regulator (CFTR) besides transcellular chloride transport, also controls the paracellular permeability of bronchial epithelium.
Günzel, Dorothee, Kusche-Vihrog, Kristina, Molenda, Natalia, Schillers, Hermann, Urbanova, Katarina, Weiser, Nelly   +5 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice [PDF]

, 2016
The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection.
Andrews, Zane B., Austin, Victoria, Barsby, Tom, Chin, Kai Yee, Ku, Jacqueline M., Miller, Alyson A., Spencer, Sarah J., Taher, Mohammadali, Wong, Connie H.Y.   +8 more
core   +1 more source

Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation

BMEMat, EarlyView.
Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu, Nan Xu, Xin Li, Xiaowo Kang, Tieyuan Bian, Junsheng Lin, Hao Tang, Yinyin Bao, Lu Zhang, Hongyan Yuan, Mingxi Yao, Xingyu Jiang, Zhi Luo   +12 more
wiley   +1 more source

Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid. [PDF]

, 2014
Hyperglycaemia as a result of diabetes mellitus or acute illness is associated with increased susceptibility to respiratory infection with Staphylococcus aureus.
A Brennan, A Sheludiakova, A Tamer, AA Pezzulo, AL Brennan, Alex J. McCarthy, AR Manolescu, BJ Philips, BJ Philips, BP Cummings, C Siebold, CA Colville, CA Merlo, CI Cheeseman, Daniela Braun, Deborah L. Baines, DM Wood, E Kupeli, EH Baker, EH Baker, Emma H. Baker, FV Donenko, G Saumon, HL Kornberg, I Knezevic, J Plumbridge, James P. Garnett, Jodi A. Lindsay, JP Garnett, JP Garnett, JP Garnett, JP Garnett, K Seidl, K Seidl, KC Strasters, KK Kalsi, KK Kalsi, KL Stanhope, M Faiyaz-Ul-Haque, Matthew R. Farrant, MM Myerburg, MT Le, ND Meadow, PA Dawson, PD Fey, PM Barker, PN Wahjudi, R Pyla, RJ Lee, SJ Curtis, YC Lee   +50 more
core   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source