Results 61 to 70 of about 328,971 (180)

Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices

Micromachines, 2019
Lung-on-a-chip (LoC) models hold the potential to rapidly change the landscape for pulmonary drug screening and therapy, giving patients more advanced and less invasive treatment options.
Timothy S. Frost, Linan Jiang, Ronald M. Lynch, Yitshak Zohar   +3 more
doaj   +1 more source

Modulation of urinary bladder paracellular permeability by stretch

The FASEB Journal, 2012
In response to bladder filling and voiding, umbrella cells undergo changes in cell‐shape and vesicular trafficking. However, it is not known how filling/voiding impact paracellular transport in these cells. To investigate how changes in umbrella cell stretch affect paracellular permeability, bladder mucosa was mounted in Ussing ...
Marcelo D Carattino, Herman S Prakasam, Wily G Ruiz, Gerard Apodaca   +3 more
openaire   +1 more source

SHED-derived exosomes ameliorate hyposalivation caused by Sjögren's syndrome via Akt/GSK-3β/Slug-mediated ZO-1 expression

Chinese Medical Journal, 2023
. Background:. Sjögren's syndrome (SS) is an autoimmune disorder characterized by sicca syndrome and/or systemic manifestations. The treatment is still challenging.
Zhihao Du, Pan Wei, Nan Jiang, Liling Wu, Chong Ding, Guangyan Yu, Lishao Guo   +6 more
doaj   +1 more source

Botulinum Toxin Type A Inhibits Submandibular Secretion via the ERK/miR-124-3p/Specificity Protein 1/Claudin-1 Axis

Cells
Botulinum toxin type A (BTXA) is widely used for the treatment of sialorrhea; however, its mechanism remains unclear. Tight junctions (TJs) are limiting factors for salivary secretion through the paracellular pathway in the salivary gland, among which ...
Qian-Ying Mao, Yan Huang, Zhuo Chen, Xiao-Feng Shan, Shang Xie, Li-Ling Wu, Ruo-Lan Xiang, Zhi-Gang Cai   +7 more
doaj   +1 more source

Feeding of deoxynivalenol increases the intestinal paracellular permeability of broiler chickens [PDF]

Archives of Toxicology, 2019
In recent years, the deleterious effects attributed to mycotoxins, in particular on the intestine, faced increased attention and it was shown that deoxynivalenol (DON) causes adverse effects on gut health. In this context, it has been repeatedly reported that DON can alter the intestinal morphology, disrupt the intestinal barrier and reduce nutrient ...
Wageha A, Awad, Daniel, Ruhnau, Claudia, Hess, Barbara, Doupovec, Dian, Schatzmayr, Michael, Hess   +5 more
openaire   +2 more sources

Effect of VCC on paracellular permeability.

, 2013
Paracellular permeability of human colon specimen (0.8 cm2) mounted in Ussing chamber to mucosal-to-serosal flux of fluorescein isothiocyanate (FITC 140 µM) was measured in the presence or absence of mucosal VCC (1 nM) or protamine (100 mg/ml).
Anna Diana (373663), Lucantonio Debellis (373662), Carlo Spirlì (373673), Marina de Bernard (278628), Piero Portincasa (44294), Donato Francesco Altomare (373671), Romina Fiorotto (373669), Diletta Arcidiacono (373666)   +7 more
core   +1 more source

Brush border membrane vesicle and Caco-2 cell line: Two experimental models for evaluation of absorption enhancing effects of saponins, bile salts, and some synthetic surfactants

Journal of Advanced Pharmaceutical Technology & Research, 2016
The aim of this study was to investigate the influence of absorption enhancers in the uptake of hydrophilic compounds. The permeation of the two hydrophilic drug models gentamicin and 5 (6)-carboxyfluorescein (CF) across the brush border membrane ...
Eskandar Moghimipour, Sayyed Abolghassem Sajadi Tabassi, Mohammad Ramezani, Somayeh Handali, Raimar Lobenberg   +4 more
doaj   +1 more source

An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence

Scientific Reports, 2023
Acyclovir, an antiviral drug, has low bioavailability due to its low permeability. Consequently, high drug doses and frequent administration are required.
Omar Y. Mady, Sara Mohsen Thabit, Suzan E. Abo Elnasr, Asmaa A. Hedaya   +3 more
doaj   +1 more source

The impact of pathogenic and artificial mutations on Claudin-5 selectivity from molecular dynamics simulations

Computational and Structural Biotechnology Journal, 2023
Tight-junctions (TJs) are multi-protein complexes between adjacent endothelial or epithelial cells. In the blood-brain-barrier (BBB), they seal the paracellular space and the Claudin-5 (Cldn5) protein forms their backbone. Despite the fundamental role in
Alessandro Berselli, Giulio Alberini, Fabio Benfenati, Luca Maragliano   +3 more
doaj   +1 more source

High paracellular nutrient absorption in intact bats is associated with high paracellular permeability in perfused intestinal segments [PDF]

Journal of Experimental Biology, 2014
Abstract Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular mechanisms. Based on a few previous studies, the capacity for paracellular nutrient absorption seems greater in flying mammals than in nonflying mammals, but there has been little investigation of the mechanisms driving this difference ...
Brun, Antonio, Price, Edwin R., Gontero-Fourcade, Manuel N., Fernandez-Marinone, Guido, Cruz-Neto, Ariovaldo P., Karasov, William H., Caviedes-Vidal, Enrique   +6 more
openaire   +4 more sources