Results 51 to 60 of about 328,971 (180)

Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress

Redox Biology, 2022
Background: Oxidative stress and the resultant hyperpermeability play a vital role in the pathogenesis of diabetic retinopathy (DR). Poldip2 has been implicated in H2O2 production, but the effects of capsaicin on poldip2 have not been reported.
Kou Liu, Xiang Gao, Chengyang Hu, Yanchao Gui, Siyu Gui, Qinyu Ni, Liming Tao, Zhengxuan Jiang   +7 more
doaj   +1 more source

Ionizing Radiation Enhances Paracellular Permeability Through Alteration of Intercellular Junctions in Cultured Human Lymphatic Endothelial Cells [PDF]

, 2018
Background: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability.
Furudoi, Shungo, Kakei, Yasumasa, Komori, Takahide, Kishimoto, Megumi, Sakakibara, Akiko, Kusumoto, Junya, Hasegawa, Takumi, Sasaki, Ryohei, Akashi, Masaya   +8 more
core   +1 more source

Role of Luminal Calcium in the Permeation of Phytate Across Caco-2 Monolayer

Applied Biosciences
Phytate (myo-inositol hexakisphosphate) is a polyphosphate found in plant-based foods whose intestinal absorption mechanisms are insufficiently understood.
Theresa Bäuerle, Christina Kunz, Karlis Briviba   +2 more
doaj   +1 more source

Screening for effective cell-penetrating peptides with minimal impact on epithelial cells and gut commensals in vitro

Frontiers in Pharmacology, 2022
One of the biggest challenges for oral drug absorption is the epithelial barrier of the gastrointestinal tract. The use of cell-penetrating peptides (CPPs) to modulate the epithelial barrier function is known to be an effective strategy to improve drug ...
Hitesh P. Gelli, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer   +2 more
doaj   +1 more source

Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection

Viruses, 2018
The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage.
Chanettee Chanthick, Aroonroong Suttitheptumrong, Nantapon Rawarak, Sa-nga Pattanakitsakul   +3 more
doaj   +1 more source

Simple graphical approach to investigate differences in transepithelial paracellular leak pathway permeability

Physiological Reports, 2022
Although many studies have reported differences in epithelial paracellular Leak Pathway permeability following genetic manipulations and treatment with various agents, the basis for these differences remains mostly unclear.
Ashley Monaco, Josephine Axis, Kurt Amsler   +2 more
doaj   +1 more source

Trained hypertensive rats exhibit decreased transcellular vesicle trafficking, increased tight junctions’ density, restored blood-brain barrier permeability and normalized autonomic control of the circulation

Frontiers in Physiology, 2023
Introduction: Chronic hypertension is accompanied by either blood-brain barrier (BBB) leakage and autonomic dysfunction. There is no consensus on the mechanism determining increased BBB permeability within autonomic areas.
Vanessa B. Candido, Sany M. Perego, Alexandre Ceroni, Martin Metzger, Alison Colquhoun, Lisete C. Michelini   +5 more
doaj   +1 more source

Increased Slc34a2 expression and paracellular phosphate permeability contribute to high intestinal phosphate absorption in young mice [PDF]

, 2023
Aim: Phosphorus is a critical constituent of bone as a component of hydroxyapatite. Bone mineral content accrues rapidly early in life necessitating a positive phosphorus balance, which could be established by a combination of increased renal ...
Megan R. Beggs, MacDonald, Tate, O'Neill, Debbie, Alexander, R. Todd, Dimke, Henrik; id_orcid, Debbie O'Neill, R. Todd Alexander, Kozuka, Kenji, Kenji Kozuka, Henrik Dimke, Beggs, Megan R., Tate MacDonald   +11 more
core   +1 more source

TGFβs modulate permeability of the blood-epididymis barrier in an in vitro model. [PDF]

PLoS ONE, 2013
The blood-epididymis barrier (BEB) is formed by epithelial tight junctions mediating selective permeability of the epididymal epithelium. Defective barrier function can disturb the balance of the epididymal milieu, which may result in infertility.
Angelika Stammler, Dieter Müller, Yoshiaki Tabuchi, Lutz Konrad, Ralf Middendorff   +4 more
doaj   +1 more source

Anti-HLA I antibodies induce VEGF production by endothelial cells, which increases proliferation and paracellular permeability

, 2009
Anti-human leukocyte antigen class I (HLA I) antibodies were shown to activate several protein kinases in endothelial cells (ECs), which induces proliferation and cell survival.
Ligeti, Nathalie, Bieri, Jürg, Bieri, Michael, Mohacsi, Paul, Farkas, Anikò, Oroszlan, Melinda   +5 more
core   +1 more source