Results 51 to 60 of about 41,666 (255)
Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress
Redox Biology, 2022 Background: Oxidative stress and the resultant hyperpermeability play a vital role in the pathogenesis of diabetic retinopathy (DR). Poldip2 has been implicated in H2O2 production, but the effects of capsaicin on poldip2 have not been reported.
Kou Liu +7 more
doaj +1 more source
The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat [PDF]
, 2010 The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed.
Anna-Lena Ungell +12 more
core +2 more sources
Nitric oxide enhances paracellular permeability of opossum kidney cells [PDF]
Kidney International, 1999 Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the in vivo proximal tubule.Paracellular ...
Liang, Mingyu, Knox, Franklyn G.
openaire +2 more sources
Transepithelial electrical resistance (TEER): a functional parameter to monitor the quality of oviduct epithelial cells cultured on filter supports [PDF]
, 2015 Cultivation of oviduct epithelial cells on porous filters fosters in vivo-like morphology and functionality. However, due to the optical properties of the filter materials and the cells’ columnar shape, cell quality is hard to assess via light microscopy.
Chen, Shuai +2 more
core +2 more sources
Frontiers in Pharmacology, 2022 One of the biggest challenges for oral drug absorption is the epithelial barrier of the gastrointestinal tract. The use of cell-penetrating peptides (CPPs) to modulate the epithelial barrier function is known to be an effective strategy to improve drug ...
Hitesh P. Gelli +2 more
doaj +1 more source
Viruses, 2018 The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage.
Chanettee Chanthick +3 more
doaj +1 more source
Physiological Reports, 2022 Although many studies have reported differences in epithelial paracellular Leak Pathway permeability following genetic manipulations and treatment with various agents, the basis for these differences remains mostly unclear.
Ashley Monaco +2 more
doaj +1 more source
Frontiers in Physiology, 2023 Introduction: Chronic hypertension is accompanied by either blood-brain barrier (BBB) leakage and autonomic dysfunction. There is no consensus on the mechanism determining increased BBB permeability within autonomic areas.
Vanessa B. Candido +5 more
doaj +1 more source
Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]
, 2019 Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland +8 more
core +1 more source
TGFβs modulate permeability of the blood-epididymis barrier in an in vitro model. [PDF]
PLoS ONE, 2013 The blood-epididymis barrier (BEB) is formed by epithelial tight junctions mediating selective permeability of the epididymal epithelium. Defective barrier function can disturb the balance of the epididymal milieu, which may result in infertility.
Angelika Stammler +4 more
doaj +1 more source