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Regulation of paracellular permeability: factors and mechanisms
Molecular Biology Reports, 2013Epithelial permeability is composed of transcellular permeability and paracellular permeability. Paracellular permeability is controlled by tight junctions (TJs). Claudins and occludin are two major transmembrane proteins in TJs, which directly determine the paracellular permeability to different ions or large molecules.
Yan Hu +3 more
semanticscholar +4 more sources
Nanomedicine, 2021
Engineered nanoparticles (ENPs) are widely used in medical diagnosis and treatment, as food additives and as energy materials. ENPs may exert adverse or beneficial effects on the human body, which may be linked to interactions with biological barriers ...
Lan-Min Wang, Yu-ting Wang, Wan-Xi Yang
semanticscholar +1 more source
Engineered nanoparticles (ENPs) are widely used in medical diagnosis and treatment, as food additives and as energy materials. ENPs may exert adverse or beneficial effects on the human body, which may be linked to interactions with biological barriers ...
Lan-Min Wang, Yu-ting Wang, Wan-Xi Yang
semanticscholar +1 more source
Barriers to paracellular permeability in rabbit esophageal epithelium
Gastroenterology, 1992Morphological and electrophysiological techniques were used to define the location and nature of the barriers to diffusion across the intercellular space (paracellular pathway) of rabbit esophageal epithelium. Transmission electron microscopy and light microscopy coupled with histochemistry identified a series of tight junctions and an intercellular ...
R C, Orlando +3 more
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Enhancing paracellular permeability by modulating epithelial tight junctions
Pharmaceutical Science & Technology Today, 2000The intestinal epithelium is a major barrier to the absorption of hydrophilic drugs. The presence of intercellular junctional complexes, particularly the tight junctions (zona occludens), renders the epithelium impervious to hydrophilic drugs, which cannot diffuse across the cells through the lipid bilayer of the cell membranes.
, Ward, , Tippin, , Thakker
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Protamine reversibly decreases paracellular cation permeability inNecturus gallbladder
The Journal of Membrane Biology, 1985Protamine, a naturally occurring arginine-rich polycationic protein (pI 9.7 to 12), was tested in Necturus gallbladder using a transepithelial AC-impedance technique. Protamine sulfate or hydrochloride (100 micrograms/ml = 20 microM), dissolved in the mucosal bath, increased transepithelial resistance by 89% without affecting the resistance of ...
M, Fromm +3 more
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Cytoskeletal regulation of Caco‐2 intestinal monolayer paracellular permeability
Journal of Cellular Physiology, 1995AbstractAn abnormal increase in intestinal paracellular permeability may be an important pathogenic factor in various intestinal diseases. The intracellular factors and processes that regulate and cause alteration of intestinal paracellular permeability are not well understood.
T Y, Ma +5 more
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