Results 231 to 240 of about 41,666 (255)

Intestinal Paracellular Permeability is not Affected in Chronic Congestive Heart Failure

European Journal of Heart Failure, 2007
Abstract Background In chronic heart failure (CHF) it has been proposed that a dysfunction of the gastrointestinal barrier could lead to translocation of endotoxin into the systemic circulation.
M, Schaufelberger, I, Ekman, E, Björnsson, E, Kalaitzakis, T, Ekman   +4 more
openaire   +2 more sources

ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability

Journal of Dental Research, 2015
The tight junction–based paracellular pathway plays an important role in saliva secretion. Zonula occludens (ZO) proteins are submembranous proteins of tight junction complex; however, their function in salivary epithelium is poorly understood. Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin ...
J, Li, X, Cong, Y, Zhang, R L, Xiang, M, Mei, N Y, Yang, Y C, Su, S, Choi, K, Park, L W, Zhang, L L, Wu, G Y, Yu   +11 more
openaire   +2 more sources

Comparative Permeabilities of the Paracellular and Transcellular Pathways of Corneal Endothelial Layers

The Journal of Membrane Biology, 2011
Layers of rabbit corneal endothelial cells were cultured on permeable inserts. We characterized the diffusional permeability of the cell layer to nonelectrolyte and charged molecules and compared the diffusional and filtration permeabilities of the paracellular and transcellular pathways.
Friedrich P, Diecke, Verónica I, Cacace, Nicolás, Montalbetti, Li, Ma, Kunyan, Kuang, Pavel, Iserovich, Jorge, Fischbarg   +6 more
openaire   +2 more sources

The Effect of Hyperosmosis on Paracellular Permeability in Caco-2 Cell Monolayers

Bioscience, Biotechnology and Biochemistry, 2009
The intestinal epithelium is a significant barrier to oral absorption of hydrophilic compounds, and their passage through the intercellular space is restricted by the tight junctions. In this study we found that hyperosmosis is a significant factor altering paracellular transport in Caco-2 cell monolayers.
Hitoshi, Inokuchi, Takuto, Takei, Katsuyoshi, Aikawa, Makoto, Shimizu   +3 more
exaly   +3 more sources

Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1992
Many hormones and drugs exert their effects on cells by increasing cytosolic Ca2+ (Cai2+) and activating protein kinase C (PKC). Each of these actions results in cholestasis in the isolated perfused rat liver, but the responsible mechanisms are unclear.
M H, Nathanson, A, Gautam, O C, Ng, R, Bruck, J L, Boyer   +4 more
openaire   +2 more sources

Cytoskeletal regulation of Caco‐2 intestinal monolayer paracellular permeability

Journal of Cellular Physiology, 1995
AbstractAn abnormal increase in intestinal paracellular permeability may be an important pathogenic factor in various intestinal diseases. The intracellular factors and processes that regulate and cause alteration of intestinal paracellular permeability are not well understood.
T Y, Ma, D, Hollander, L T, Tran, D, Nguyen, N, Hoa, D, Bhalla   +5 more
openaire   +2 more sources

Protamine reversibly decreases paracellular cation permeability inNecturus gallbladder

The Journal of Membrane Biology, 1985
Protamine, a naturally occurring arginine-rich polycationic protein (pI 9.7 to 12), was tested in Necturus gallbladder using a transepithelial AC-impedance technique. Protamine sulfate or hydrochloride (100 micrograms/ml = 20 microM), dissolved in the mucosal bath, increased transepithelial resistance by 89% without affecting the resistance of ...
M, Fromm, C E, Palant, C J, Bentzel, U, Hegel   +3 more
openaire   +2 more sources

Cold exposure increases intestinal paracellular permeability to nutrients in the mouse

Journal of Experimental Biology, 2013
Summary In situations of increased energy demand/food intake, animals can often acclimate within several days. The intestine generally responds to elevated digestive demand by increasing in size. However, there is likely a limit to how quickly the intestine can grow to meet the new demand.
Edwin R, Price, Lisa J, Ruff, Alberto, Guerra, William H, Karasov   +3 more
openaire   +2 more sources

Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland

Journal of Cell Science, 2013
Summary Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia. We previously reported that activation of transient receptor potential vanilloid subtype 1 (TRPV1) in rabbit submandibular gland promoted salivary secretion, partly by an increase in paracellular permeability.
Xin, Cong, Yan, Zhang, Ning-Yan, Yang, Jing, Li, Chong, Ding, Qian-Wen, Ding, Yun-Chao, Su, Mei, Mei, Xiao-Hong, Guo, Li-Ling, Wu, Guang-Yan, Yu   +10 more
openaire   +2 more sources

Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation

Biochemical and Biophysical Research Communications, 2002
Butyrate may have a role in preventing ulcerative colitis, but its precise mechanism is unknown. Also, PPARgamma (peroxisome proliferator-activated receptor gamma) is expressed at high levels both in the colonic epithelium and colon cancer cell lines, but no report was shown on the relationship between PPARgamma activation and the effect of butyrate ...
Mako, Kinoshita, Yasuo, Suzuki, Yasushi, Saito   +2 more
openaire   +2 more sources