Results 221 to 230 of about 666,834 (274)

Lucifer Yellow - A Robust Paracellular Permeability Marker in a Cell Model of the Human Blood-brain Barrier.

Journal of Visualized Experiments, 2019
The blood-brain barrier BBB consists of endothelial cells that form a barrier between the systemic circulation and the brain to prevent the exchange of non-essential ions and toxic substances.
Wanzhu Zhao, Linjiang Han, Y. Bae, D. Manickam   +3 more
semanticscholar   +1 more source

Modulation of Endothelial Paracellular Permeability

1992
Inflammatory edema is a significant element of many disease, e.g., adult respiratory distress syndrome, septicemia, and hypoxia/reperfusion syndrome. In vivo studies have sought to identify the mechanism(s) by which inflammatory mediators produce edema.
F. R. Haselton, J. S. Alexander, S. N. Mueller, A. P. Fishman   +3 more
openaire   +1 more source

Modulation of epithelial and endothelial paracellular permeability by leukocytes

Advanced Drug Delivery Reviews, 2000
The tight junction acts as a regulated barrier for diffusion of ions, larger solutes, and migration of leukocytes through the paracellular space. Barrier function varies with the tissue type, and positively correlates with the number and complexity of tight junction strand formation.
H A, Edens, C A, Parkos
openaire   +2 more sources

Endotoxin increases paracellular permeability of isolated rat hepatocyte couplets

Hepatology Research, 2001
Hyperbilirubinemia is frequently associated with endotoxemia. Regurgitation of bile constituents including bilirubin into the sinusoidal space is prevented by tight junctions which maintain paracellular permeability between hepatocytes. To investigate the mechanism of endotoxin-associated hyperbilirubinemia, we have studied the changes in paracellular ...
T, Kawaguchi, S, Sakisaka, M, Harada, S, Hanada, E, Taniguchi, H, Koga, K, Sasatomi, K, Tanikawa, M, Sata   +8 more
openaire   +2 more sources

Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation

Biochemical and Biophysical Research Communications, 2002
Butyrate may have a role in preventing ulcerative colitis, but its precise mechanism is unknown. Also, PPARgamma (peroxisome proliferator-activated receptor gamma) is expressed at high levels both in the colonic epithelium and colon cancer cell lines, but no report was shown on the relationship between PPARgamma activation and the effect of butyrate ...
Mako, Kinoshita, Yasuo, Suzuki, Yasushi, Saito   +2 more
openaire   +2 more sources

Nonelectrolyte permeability of the paracellular pathway in Necturus proximal tubule

American Journal of Physiology-Legacy Content, 1975
Micropuncture experiments were performed on Necturus proximal tubule using stationary microperfusion and microrecollection techniques. The transepithelial movement of the extracellular marker, sucrose, was used to investigate the passive permeability of the paracellular shunt pathway under steady-state conditions, during spontaneous reabsorption and ...
C A, Berry, E L, Boulpaep
openaire   +2 more sources

Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1992
Many hormones and drugs exert their effects on cells by increasing cytosolic Ca2+ (Cai2+) and activating protein kinase C (PKC). Each of these actions results in cholestasis in the isolated perfused rat liver, but the responsible mechanisms are unclear.
M H, Nathanson, A, Gautam, O C, Ng, R, Bruck, J L, Boyer   +4 more
openaire   +2 more sources

Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001
Previous studies found that monolayers formed from canine oxyntic epithelial cells in primary culture displayed remarkable resistance to apical acidification and both mitogenic and migratory responses to epidermal growth factor (EGF) treatment. In our present studies, we found that EGF increased transepithelial resistance (TER) but not short-circuit ...
M C, Chen, J, Goliger, N, Bunnett, A H, Soll   +3 more
openaire   +2 more sources

Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway.

Molecular Pharmaceutics, 2018
Hydrophilic peptides constitute most of the active peptides. They mostly permeate via tight junctions (paracellular pathway) in the intestine. This permeability mechanism restricts the magnitude of their oral absorption and bioavailability.
Adi Schumacher-Klinger, Joseph Fanous, Shira Merzbach, M. Weinmüller, F. Reichart, Andreas F B Räder, Agata Gitlin-Domagalska, C. Gilon, H. Kessler, A. Hoffman   +9 more
semanticscholar   +1 more source

Modulation of intestinal paracellular permeability by intracellular mediators and cytoskeleton

Canadian Journal of Physiology and Pharmacology, 1997
The influence of cytoskeletal inhibitors (cytochalasin E and colchicine) and intracellular mediators (cAMP, Ca2+, and protein kinase C) in the control of paracellular permeability to mannitol has been examined in rat jejunum in Ussing-type chambers. Cytoskeletal inhibitors, cytochalasin E (20 mumol.L-1) or colchicine (0.5 mmol.L-1), when present in ...
M, Pérez, A, Barber, F, Ponz
openaire   +2 more sources