Results 231 to 240 of about 666,834 (274)
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Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways
Annual Review of Physiology, 2010The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis and transmigration of leukocytes and providing essential nutrients across the vessel wall. Transport of plasma proteins and solutes across the endothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport, and the other ...
Yulia, Komarova, Asrar B, Malik
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Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
Surgery, 2002We have previously shown minimal evidence of neutrophil infiltration during early reperfusion of porcine ischemic ileum. However, we noted marked neutrophil infiltration 6 to 18 hours after ischemia during mucosal repair. We postulated such neutrophil infiltration would disrupt restituting epithelium.Pigs were pretreated with anti-CD11/CD18 monoclonal ...
J'mai, Gayle +3 more
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Nucleotide regulation of paracellular Cl− permeability in natural rabbit airway epithelium
Pflügers Archiv - European Journal of Physiology, 2005In this study, we demonstrate a novel regulatory mechanism by which mucosal nucleotides via P2Y receptors decrease paracellular Cl(-) ion permeability in natural rabbit airway epithelium (in addition to a decrease in active Na(+) absorption). In contrast to primary cultures, the natural airway epithelium is a low-resistance epithelium, and an ...
Poulsen, A.N. +4 more
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Revisiting the Stool Microbiome: Intestinal Paracellular Permeability Connection
Gastroenterology, 2023Jonathan D. Kaunitz, Daniel Hollander
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Tight junctions and paracellular permeability in cultured bovine corneal endothelial cells
Graefe's Archive for Clinical and Experimental Ophthalmology, 1994Intramembrane specializations of cultured bovine corneal endothelial cells were studied with thin section and freeze-fracture electron microscopy and related to the paracellular permeability and the transendothelial resistance (Rt) of the monolayers. The following intercellular junctions were found: single and discontinuous networks of tight junctions (
W, Noske +4 more
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Glutamate transport modulation of paracellular permeability across LLC-PK1-F+ monolayers
American Journal of Physiology-Endocrinology and Metabolism, 1996Welbourne, T. C., D. Chevalier, and X. Mu. Glutamate transport modulation of paracellular permeability across LLC-PK 1 -F + monolayers. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E889-E895, 1996.-The role of extracellular glutamate in modulating paracellular permeability was assessed in proximal tubulelike LLC-PK 1 -F + cells and the rabbit kidney ...
T C, Welbourne, D, Chevalier, X, Mu
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PERMEABILITY OF MYOCARDIAL CAPILLARIES TO HYDROPHILIC DRUGS: THE PARACELLULAR PATHWAY
Clinical and Experimental Pharmacology and Physiology, 1996SUMMARY1. As the majority of drug molecules are relatively small and lipophilic, capillary uptake in those regions with a continuous endothelium, such as the heart, has generally been regarded as taking place by flow‐limited transcellular capillary transport.
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American Journal of Physiology-Cell Physiology, 1997
Extracellular ATP stimulates a biphasic change in transepithelial electrical resistance (RTE) across cultures of human cervical epithelial cells: an acute decrease (phase I), followed by a delayed increase in resistance (phase II). The objective of this study was to determine the contributions of changes in the lateral intercellular space resistance ...
G I, Gorodeski, J, Goldfarb
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Extracellular ATP stimulates a biphasic change in transepithelial electrical resistance (RTE) across cultures of human cervical epithelial cells: an acute decrease (phase I), followed by a delayed increase in resistance (phase II). The objective of this study was to determine the contributions of changes in the lateral intercellular space resistance ...
G I, Gorodeski, J, Goldfarb
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Intestinal paracellular permeability is not affected in chronic congestive heart failure
European Journal of Heart Failure, 2007AbstractBackground:In chronic heart failure (CHF) it has been proposed that a dysfunction of the gastrointestinal barrier could lead to translocation of endotoxin into the systemic circulation. A secondary inflammatory reaction, observed as increased levels of cytokines, could negatively affect cardiac function. The aims of this paper were therefore to
M, Schaufelberger +4 more
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Regulation of endothelial cell gap formation and paracellular permeability.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1995Investigation of the regulation of permeability properties of the endothelium has yielded evidence to support the concept of a dual regulation of EC gap formation and barrier function. In this model, the primary determinants of EC permeability are tethering/adhesive properties (Figure 1) and tensile centripetal force generation (Figure 2).
J G, Garcia, K L, Schaphorst
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