Results 41 to 50 of about 10,332 (185)

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Psychotropic medication involved in intentional drug overdose: implications for treatment. [PDF]

, 2013
Aims: Limited information is available on the source of medications taken in intentional drug overdoses (IDOs). The present study aimed to investigate the proportion of patients who engaged in IDOs with current prescriptions and the proportion of those ...
Arensman, Ella, Corcoran, Paul, Griffin, Eve, Heavey, Breda, Perry, Ivan J   +4 more
core   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Antidotes for childhood toxidromes

Drugs in Context, 2021
Background: Poisoning causes significant morbidity and sometimes mortality in children worldwide. The clinical skill of toxidrome recognition followed by the timely administration of an antidote specific for the poison is essential for the management of ...
Kam Lun Hon, Wun Fung Hui, Alexander KC Leung   +2 more
doaj   +1 more source

Measuring the impact of medicines regulatory interventions - systematic review and methodological considerations [PDF]

, 2017
Aim: Evaluating the public health impact of regulatory interventions is important but there is currently no common methodological approach to guide this evaluation.
Acheampong, Arana, Arlett, Barber, Bateman, Bedson, Bergen, Bester, Bhatia, Bouvy, Bowen, Breen, Briesacher, Brinker, Burkhart, Busch, Bushnell, Carlson, Carracedo-Martinez, Castaneda, Ceilley, Cepeda, Chol, Cluxton, Cohen, Crijns, Crijns, Crijns, Czajkowski, Deslandes, DiSantostefano, Donohoe, Dorsey, Du, Dusetzina, Ehrenstein, Einarson, Enger, Eworuke, Eworuke, Exton, Farmer, Feldstein, Flood, Forrester, Garbutt, Garg, Gibbons, Gleason, Gorman, Graham, Greene, Gridchyna, Gunnell, Guo, Guthrie, Guzman, Habib, Hagiwara, Hampton, Hanatani, Handley, Hassanin, Hawkins, Hawton, Hawton, Hawton, Hawton, Hawton, Hawton, Henry, Herdeiro, Hernandez, Hollingsworth, Holmes, Hsu, Hughes, Inglis, Ishihara, Jandoc, Kales, Katz, Kesselheim, Kessler, Kimura, Kornfield, Kruik-Kollöffel, Kurdyak, Kurian, Laffoy, Laporte, Leal, Leclerc-Foucras, Libby, Libby, Lokker, Lopez Bernal, Lu, Martin, Martin, McIlroy, Metcalfe, Mitchell, Mittal, Morgan, Morgan, Morgan, Morrato, Morrato, Morrato, Musleh, Narayan, Nemeroff, Newsome, Nyeland, Olfson, Ooba, Orrico, Pamer, Paschall, Pastuszak, Piening, Richards, Robertson, Ruiter, Sandilands, Sanfelix-Gimeno, Schachtele, Schaefer, Shah, Sharpe, Shatin, Sheen, Sheen, Shehab, Simonoff, Singh, Smalley, Starner, Stewart, Stockl, Sultana, Sumi, Teichert, Thomas, Thompson, Thomson, Tricotel, Tuchscherer, Valiyeva, Valkhoff, Valluri, Valuck, Wagner, Watson, Wax, Weatherby, Weatherby, Wheeler, Wheeler, Wijlaars, Wilkinson, Willy, Wood, Wright, Zomerdijk   +165 more
core   +3 more sources

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Trends in long-term prescribing of dependence forming medicines [PDF]

, 2019
Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S., Nguyen, A., Sehmi, R., Smith, N.   +3 more
core  

Paracetamol orodispersible tablets: a risk for severe poisoning in children? [PDF]

, 2018
Purpose: Childhood paracetamol (acetaminophen) ingestion with subsequent risk of hepatotoxicity is a major medical problem. The aim of this study was to investigate the risk of high-dose ingestion of orodispersible, fast-disintegrating paracetamol ...
Ceschi, Alessandro, Hofer, Katharina, Kupferschmidt, Hugo, Rauber-Lüthy, Christine   +3 more
core  

Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice [PDF]

, 2018
Introduction: In this study, we aimed to evaluate the protective effects of Descurainia sophia seed extract on paracetamol-induced oxidative stress and acute liver injury in mice. Methods: Sixty male Swiss albino mice were divided into 6 groups, group I:
Faed Maleki, Firouz, Iman, Maryam, Khamesipour, Ali, Moshaie-Nezhad, Pedram   +3 more
core   +2 more sources