Results 51 to 60 of about 117,311 (162)

Stocks of paracetamol products stored in urban New Zealand households: A cross-sectional study.

PLoS ONE, 2020
BackgroundIntentional self-harm is a common cause of hospital presentations in New Zealand and across the world, and self-poisoning is the most common method of self-harm. Paracetamol (acetaminophen) is frequently used in impulsive intentional overdoses,
Eeva-Katri Kumpula, Pauline Norris, Adam C Pomerleau   +2 more
doaj   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3191-3201, September 2026.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Self-poisoning with paracetamol in England: short report of characteristics of individuals and their overdoses according to source of tablets

BJPsych Open
Self-poisoning with paracetamol is the most frequently used overdose method in the UK. Psychosocial assessments were conducted by mental health clinicians with 127 consecutive individuals who presented with pure paracetamol overdoses to a large general ...
Fiona Brand, Elizabeth Bale, Apostolos Tsiachristas, Keith Hawton   +3 more
doaj   +1 more source

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 795-805, September 2026.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Changing paradigms of paracetamol poisoning

, 2020
The overall objective of this thesis was to identify and examine areas for improvement in the management of paracetamol poisoning. Paracetamol is one of the commonest drugs taken in overdose in Australia and a common cause of acute liver injury in ...
Chiew, Angela
core  

Oral Copaiba Oil‐Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic‐Obese Animals

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Oral supplementation with copaiba‐oil resin (Co‐resin) restores hepatic and plasma oxidative systems in hypothalamic‐obese male and female rats, therefore, it showed a more positive impact on females. This study highlights the therapeutic potential of Co‐resin to reduce reactive oxygen species production and restore plasma and hepatic antioxidant ...
Sirlei P. Souza, Zoé M. N. de Carvalho, Beatriz M. Daudt, Marianela A. F. Urrutia, Caroline M. Aguiar, Ellen C. Z. Gomes, Mustafa M. M. Dahleh, Marina Prigol, Gustavo P. Guerra, Lucinéia F. C. Ribeiro, Sabrina Grassiolli   +10 more
wiley   +1 more source

The effect of recalling paracetamol on hospital admissions for poisoning in Western Australia

, 2003
Objectives: To assess the effect of two recalls of paracetamol products on rates of intentional and unintentional overdoses of paracetamol in all age groups, as well as any effect on poisoning by other agents.
Preston, NJ, Kisely, SR, Lawrence, D
core  

Clinician Perspectives on Prescribing Restrictions and Opioid Pain Management in Australian Podiatric Practice: A Qualitative Study

Journal of Foot and Ankle Research, Volume 19, Issue 3, September 2026.
ABSTRACT Background Australian‐endorsed general podiatrists and podiatric surgeons (EGPs and EPSs, respectively) operate under a fixed prescribing formulary, the National Podiatry Scheduled Medicines List (NPSML), that restricts access to opioid analgesics including tramadol and tapentadol, despite emerging evidence questioning the efficacy of ...
Lachlan Aquilina, Mischa Kronenberg, Estie Kruger, Marc Tennant, Joon Soo Park   +4 more
wiley   +1 more source

Design And Evaluation Of Controlled Release Layered Matrix Tablets Of Paracetamol And Verapamil Hci. [PDF]

, 2009
Tablet matriks berlapis pelepasan terkawal parasetamol dan verapamil HCl dibangunkan menggunakan polimer hidrofilik dan hidrofobik, dan disediakan dengan kaedah pengranulan basah.
Rahamathullah, Shaikh
core   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source