Results 41 to 50 of about 4,243 (161)

Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Etiological agents are Paracoccidioides species that diverge phylogenetically throughout South America. OBJECTIVES This study aimed to document the epidemiology of
Primavera Alvarado, Marcus de Melo Teixeira, Elsy Cavallera, Hugo Costa Paes, Giovanni Guerra, Gerardo Santander, Rommie Merino-Alado   +6 more
doaj   +1 more source

Integrated In Silico – In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action

Global Challenges, EarlyView.
This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni, Katharina Fuchs, Gianni Galaverna, Peter Macheroux, Luca Dellafiora   +4 more
wiley   +1 more source

Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus.

PLoS Neglected Tropical Diseases, 2015
BackgroundHypoxic microenvironments are generated during fungal infection. It has been described that to survive in the human host, fungi must also tolerate and overcome in vivo microenvironmental stress conditions including low oxygen tension; however ...
Patrícia de Sousa Lima, Dawoon Chung, Alexandre Melo Bailão, Robert A Cramer, Célia Maria de Almeida Soares   +4 more
doaj   +1 more source

Fungal DNA‐barcoding on a chip: Magnetoresistive biosensors for yeast infection diagnosis

VIEW, EarlyView.
The development of a fungal pathogen identification chip is herein demonstrated. Hybridization dynamics were tested against 58 species in silico and 4 species on chip. 95% accuracy, 91% sensitivity, 98% specificity and femtomolar limit of detection were achieved. Future perspectives include the integration of sample pre‐treatment modules.
Maria Zolotareva, Francisco Cascalheira, Rúben Afonso, Maria Corado, Ana Martins, Cátia Caneiras, Cristina Bárbara, Miguel Cacho Teixeira, Diogo Miguel Caetano   +8 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp.

Journal of Fungi, 2022
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus.
Alessandra G. Krakhecke-Teixeira, Danielle H. Yamauchi, Alexsandra Rossi, Herdson R. de Sousa, Hans G. Garces, Joaquim L. Júnior, Antônio O. S. Júnior, Maria Sueli S. Felipe, Eduardo Bagagli, Heitor F. de Andrade, Marcus de M. Teixeira   +10 more
doaj   +1 more source

Extracellular Vesicles From Fungal Infection in Humans: A Key Player in Immunological Responses

Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.
ABSTRACT Fungal infections cause approximately 1.6 million deaths annually. Diagnosing and treating fungal infections is difficult due to limited access to diagnostic tests and rising antifungal resistance. Extracellular vesicles (EVs) facilitate interactions between fungal cells and hosts, significantly influencing the pathogen‐host relationship ...
Caroline P. de Rezende, Patrick W. S. Santos, Renan A. Piraine, Virgínia C. Silvestrini, Julio C. J. Barbosa, Fabiana C. P. Valera, Edwin Tamashiro, Guilherme G. Podolski‐Gondim, Silvana M. Quintana, Rodrigo Calado, Roberto Martinez, Taicia P. Fill, Márcio L. Rodrigues, Fausto Almeida   +13 more
wiley   +1 more source

Production of prostaglandins and leukotrienes by Paracoccidioides brasiliensis [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
Sao Paulo State Univ, UNESP, Fac Med Botucatu, Dept Doencas Trop,Botucatu Med Sch, BR-18618000 Botucatu, SP ...
openaire   +6 more sources

Climate Change, Natural Disasters, and Cutaneous Fungal Infections

International Journal of Dermatology, Volume 64, Issue 8, Page 1349-1355, August 2025.
ABSTRACT Fungal infections are an important source of morbidity and mortality that can manifest as superficial or invasive diseases. Diagnostic techniques for human fungal pathogens remain problematic, and multi‐drug resistance is emerging. This review addresses the potential emergence of new fungal pathogens in changing environments and reported ...
Aditya K. Gupta, Mary Thornbush, Tong Wang   +2 more
wiley   +1 more source

A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp.

PLoS Neglected Tropical Diseases, 2019
Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete ...
Patrícia Albuquerque, André Moraes Nicola, Diogo Almeida Gomes Magnabosco, Lorena da Silveira Derengowski, Luana Soares Crisóstomo, Luciano Costa Gomes Xavier, Stefânia de Oliveira Frazão, Fernanda Guilhelmelli, Marco Antônio de Oliveira, Jhones do Nascimento Dias, Fabián Andrés Hurtado, Marcus de Melo Teixeira, Allan Jefferson Guimarães, Hugo Costa Paes, Eduardo Bagagli, Maria Sueli Soares Felipe, Arturo Casadevall, Ildinete Silva-Pereira   +17 more
doaj   +1 more source