Results 101 to 110 of about 2,750 (239)

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Scientific Reports, 2022
A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the
Max Fleckenstein, Kevin Herr, Franziska Theiß, Stephan Knecht, Laura Wienands, Martin Brodrecht, Michael Reggelin, Gerd Buntkowsky   +7 more
doaj   +1 more source

Schnelle RASER‐MRT

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Schnelle RASER‐MRT ermöglicht Bildgebung ohne RF‐Anregung. Stattdessen wird eine Populationsinversion der Kernspins durch SABRE‐Hyperpolarisation erzeugt, die eine Selbstanregung durch RASER ermöglicht. Wenn die gewünschte transversale Magnetisierung aufgebaut ist, wird herkömmliche EPI‐Kodierung ausgelöst, um das Bild aufzuzeichnen.
Sören Lehmkuhl, Simon Fleischer, Jing Yang, Eduard Y. Chekmenev, Thomas Theis, Stephan Appelt, Jan G. Korvink, Mazin Jouda   +7 more
wiley   +1 more source

Real Time Nuclear Magnetic Resonance Detection of Fumarase Activity using Parahydrogen-Hyperpolarized [1-13C]fumarate

, 2019
Hyperpolarized fumarate can be used as a probe of real-time metabolism in vivo, using carbon-13 magnetic resonance imaging. Dissolution dynamic nuclear polarization is commonly used to produce hyperpolarized fumarate, but a cheaper and faster alternative
Francesca, Reineri, Carla, Carrera, Silvio, Aime, Eleonora, Cavallari, Dmitry, Budker, James, Eills   +5 more
core   +1 more source

A HIGH-FIDELITY, CONTINUOUS ORTHO-PARAHYDROGEN MEASUREMENT AND CONVERSION SYSTEM

, 2021
Production and consumption of liquid hydrogen is set to increase many orders of magnitude in the upcoming decades. Yet an entire liquid shipment can be boiled-off from the exothermic ortho-parahydrogen reaction if not performed during liquefaction ...
Bunge, Carl
core   +1 more source

15N NMR Hyperpolarization of Radiosensitizing Antibiotic Nimorazole via Reversible Parahydrogen Exchange in Microtesla Magnetic Fields.

Angewandte Chemie, 2020
Nimorazole belongs to the imidazole-based family of antibiotics to fight against anaerobic bacteria. Moreover, nimorazole is now in Phase 3 clinical trial in Europe for potential use as a hypoxia radiosensitizer for treatment of head and neck cancers. We
O. G. Salnikov, N. Chukanov, A. Svyatova, I. A. Trofimov, Mohammad Shah Hafez Kabir, J. Gelovani, K. Kovtunov, I. Koptyug, E. Chekmenev   +8 more
semanticscholar   +1 more source

13C MRI of hyperpolarized pyruvate at 120 µT

Scientific Reports
Nuclear spin hyperpolarization increases the sensitivity of magnetic resonance dramatically, enabling many new applications, including real-time metabolic imaging.
Nicolas Kempf, Rainer Körber, Markus Plaumann, Andrey N. Pravdivtsev, Jörn Engelmann, Johannes Boldt, Klaus Scheffler, Thomas Theis, Kai Buckenmaier   +8 more
doaj   +1 more source

Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields

Magnetochemistry
Hyperpolarization (HP) techniques, such as Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and dissolution Dynamic Nuclear Polarization (d-DNP), significantly enhance the sensitivity of nuclear magnetic ...
Garrett L. Wibbels, Clementinah Oladun, Tanner Y. O’Hara, Isaiah Adelabu, Joshua E. Robinson, Firoz Ahmed, Zachary T. Bender, Anna Samoilenko, Joseph Gyesi, Larisa M. Kovtunova, Oleg G. Salnikov, Igor V. Koptyug, Boyd M. Goodson, W. Michael Snow, Eduard Y. Chekmenev, Roman V. Shchepin   +15 more
doaj   +1 more source

Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field

Advanced Science, 2023
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism and cell regulation in both plants and humans. NMR provides interesting opportunities to investigate these metabolic pathways, yet lacks sensitivity, especially in case
Ewoud Vaneeckhaute, Jean‐Max Tyburn, James G. Kempf, Johan A. Martens, Eric Breynaert   +4 more
doaj   +1 more source

PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI

Scientific Reports, 2021
Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is ...
Alexandra Svyatova, Vitaly P. Kozinenko, Nikita V. Chukanov, Dudari B. Burueva, Eduard Y. Chekmenev, Yu-Wen Chen, Dennis W. Hwang, Kirill V. Kovtunov, Igor V. Koptyug   +8 more
doaj   +1 more source

Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K

, 2021
We report on a robust and low-cost parahydrogen generator design employing liquid nitrogen as coolant. The core of the generator consists of catalyst-filled spiral copper tubing, which can be pressurized to 35 atm. Parahydrogen fraction >48% was obtained
Chapman, Benjamin, Eduard Y. Chekmenev, Oleg G. Salnikov, Baptiste Joalland, Meersman, Collier, Chekmenev, Eduard Y., Nikolaou, Panayiotis, Koptyug, Igor V., Jessica Ettedgui, Swenson, Rolf E., Joalland, Baptiste, Rolf E. Swenson, Gemeinhardt, Max E., Krishna, Murali C., Kirill V. Kovtunov, Boyd M. Goodson, Shchepin, Roman V., Collier Meersman, Benjamin Chapman, Max E. Gemeinhardt, Salnikov, Oleg G., Igor V. Koptyug, Ettedgui, Jessica, Roman V. Shchepin, Goodson, Boyd M., Panayiotis Nikolaou, Murali C. Krishna, Kovtunov, Kirill V.   +27 more
core   +1 more source