Results 51 to 60 of about 736 (155)

Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents

Chemistry – A European Journal, 2021
AbstractMany MRI contrast agents formed with the parahydrogen‐induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high ...
Baptiste Joalland, Nuwandi M. Ariyasingha, Hassan R. Younes, Shiraz Nantogma, Oleg G. Salnikov, Nikita V. Chukanov, Kirill V. Kovtunov, Igor V. Koptyug, Juri G. Gelovani, Eduard Y. Chekmenev   +9 more
openaire   +3 more sources

Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange

Nature Communications, 2019
There is increasing effort to improve the signal sensitivity and explore the hyperpolarization dynamics. Here the authors demonstrate the parahydrogen spin transfer dynamics in compounds containing 15N using SABRE hyperpolarization technique with ...
Jacob R. Lindale, Shannon L. Eriksson, Christian P. N. Tanner, Zijian Zhou, Johannes F. P. Colell, Guannan Zhang, Junu Bae, Eduard Y. Chekmenev, Thomas Theis, Warren S. Warren   +9 more
doaj   +1 more source

Advances in Parahydrogen‐Induced Polarization for Nuclear Magnetic Resonance of Peptides, Proteins, and Biopolymers

ChemistryEurope, EarlyView.
Hyperpolarization by parahydrogen‐induced polarization enhances the sensitivity of nuclear magnetic resonance spectroscopy of amino acids, peptides, mini‐proteins, and biopolymers using nonnatural amino acids with unsaturated side chains up to three orders of magnitude.
Gerd Buntkowsky
wiley   +1 more source

Efficient 15N hyperpolarization of [15N3]metronidazole antibiotic via spin-relayed pulsed SABRE-SHEATH

Journal of Magnetic Resonance Open
Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei (SABRE-SHEATH) is an NMR hyperpolarization technique that relies of the simultaneous exchange of parahydrogen and a to-be-hyperpolarized molecule on the ...
Shiraz Nantogma, Shannon L. Eriksson, Thomas Theis, Warren S. Warren, Boyd M. Goodson, Eduard Y. Chekmenev   +5 more
doaj   +1 more source

Perpetual hyperpolarization of allyl acetate from parahydrogen and continuous flow heterogeneous hydrogenation with recycling of unreacted propargyl acetate

Journal of Magnetic Resonance Open, 2022
A novel closed loop, continuous flow (CF) reactor system for parahydrogen enhanced nuclear magnetic resonance (NMR) of liquids via heterogeneous catalysis is introduced which enables recycling of unreacted liquid substrate reactant.
Tommy Yunpu Zhao, Michelle P. Lapak, Ranjan Behera, Hanqin Zhao, Maria-Jose Ferrer, Helena E. Hagelin Weaver, Wenyu Huang, Clifford R. Bowers   +7 more
doaj   +1 more source

New para‐hydrogen cold neutron source at the Budapest Research Reactor: Monte Carlo simulations

Journal of Applied Crystallography, EarlyView.
This paper explores the options for upgrading the cold neutron source at the Budapest Research Reactor.The planned upgrade of the neutron guide system at the Budapest Research Reactor (BRR) provides an opportunity to enhance the performance of its cold neutron source.
Dmitrii Shapiro, Petr Konik, Mina Akhyani, Alexander Ioffe   +3 more
wiley   +1 more source

Schnelle RASER‐MRT

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Schnelle RASER‐MRT ermöglicht Bildgebung ohne RF‐Anregung. Stattdessen wird eine Populationsinversion der Kernspins durch SABRE‐Hyperpolarisation erzeugt, die eine Selbstanregung durch RASER ermöglicht. Wenn die gewünschte transversale Magnetisierung aufgebaut ist, wird herkömmliche EPI‐Kodierung ausgelöst, um das Bild aufzuzeichnen.
Sören Lehmkuhl, Simon Fleischer, Jing Yang, Eduard Y. Chekmenev, Thomas Theis, Stephan Appelt, Jan G. Korvink, Mazin Jouda   +7 more
wiley   +1 more source

Parahydrogen-induced polarization allows 2000-fold signal enhancement in biologically active derivatives of the peptide-based drug octreotide

Scientific Reports, 2023
Octreotide, a somatostatin analogue, has shown its efficacy for the diagnostics and treatment of various types of cancer, i.e., in octreotide scan, as radio-marker after labelling with a radiopharmaceutical.
Jonas Lins, Yuliya A. Miloslavina, Stefania C. Carrara, Lorenz Rösler, Sarah Hofmann, Kevin Herr, Franziska Theiß, Laura Wienands, Olga Avrutina, Harald Kolmar, Gerd Buntkowsky   +10 more
doaj   +1 more source

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Scientific Reports, 2022
A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the
Max Fleckenstein, Kevin Herr, Franziska Theiß, Stephan Knecht, Laura Wienands, Martin Brodrecht, Michael Reggelin, Gerd Buntkowsky   +7 more
doaj   +1 more source

Robust parahydrogen-induced polarization at high concentrations. [PDF]

Sci Adv
Parahydrogen-induced polarization (PHIP) is a potent technique for generating target molecules with high nuclear spin polarization. The PHIP process involves a chemical reaction between parahydrogen and a target molecule, followed by the transformation of nuclear singlet spin order into magnetization of a designated target nucleus through magnetic ...
Dagys L, Korzeczek MC, Parker AJ, Eills J, Blanchard JW, Bengs C, Levitt MH, Knecht S, Schwartz I, Plenio MB.   +9 more
europepmc   +7 more sources