Results 81 to 90 of about 26,778,061 (298)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characteristics of Dissolved Organic Carbon Components and Their Responses to Carbon Degradation Genes in Black Soil Under Long-Term Fertilization

Agronomy
Dissolved organic carbon (DOC) represents the most readily available and crucial carbon source for soil microorganisms, influencing their community structure, nutrient cycling, and metabolic functions.
Xiaoyu Han, Wenyan Shen, Enjiang Xiong, Hongfang Liu, Renlian Zhang, Zhimei Sun, Shuxiang Zhang   +6 more
doaj   +1 more source

Comparison of factor retention methods on binary data: A simulation study

Turkish Journal of Education, 2019
In this study, the purpose is to compare factor retention methods under simulation conditions. For this purpose, simulations conditions with a number of factors (1, 2 [simple]), sample sizes (250, 1.000, and 3.000), number of items (20, 30), average ...
Abdullah Faruk Kılıç, İbrahim Uysal
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

PC-Grade Parallel Processing and Hardware Acceleration for Large-Scale Data Analysis [PDF]

Arguably, modern graphics processing units (GPU) are the first commodity, and desktop parallel processor. Although GPU programming was originated from the interactive rendering in graphical applications such as computer games, researchers in the field ...
Yang, Su
core   +3 more sources

Fast Decomposition of Single Excitation–Emission Matrix Fluorescence Spectrum via Encoder–Decoder Model

Photonics
Three–dimensional excitation–emission matrix (3D–EEM) fluorescence spectroscopy is widely applied for the rapid characterization of dissolved organic matter (DOM) in aquatic environments.
Zhenjie Zhou, Qingtao Wu, Xiaoping Wang
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Parallel analysis and MBI-HSS: How many factors?

Colombia Medica, 2013
It has been only recently possible to validate the Maslach Burnout Inventory-Human Services Survey (MBI-HSS) among health professionals of Cali2, an important step for using this  instrument with local empirical support in regard to its reliability of scoring and internal structure.
Soto, Cesar Merino, Ramos, Marisol Angulo   +1 more
openaire   +5 more sources

Seasonal Variation in Fluorescent Dissolved Organic Matter Composition in Poyang Lake, China

Hydrology
Seasonal hydrological variation can reorganize fluorescent dissolved organic matter (FDOM) in floodplain lakes; yet, its expression in Poyang Lake remains uncertain. We assessed campaign differences in FDOM composition by comparing 32 excitation–emission
Yiling Zhong, Haiqing Liao, Fang Yang, Meng Zhang, Yuanyan Zhang, Yule Luo, Yuying Shi, Zitong Huang   +7 more
doaj   +1 more source