Results 51 to 60 of about 33,423 (302)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

计算机辅助几何法分析4-DOF并联机器人

Jixie chuandong, 2010
A novel computer aided geometry approach for type synthesis and analysis of new spatial 4-DOF parallel manipulators is put forward, and the computer simulation mechanisms of parallel manipulators is created by using the geometric constraints and ...
陈立辉, 张艳华, 杜秀菊, 杜彦蕊   +3 more
doaj  

Parallel Continuum Delta: On the Performance Analysis of Flexible Quasi-Translational Robots

Applied Sciences
In the field of rigid parallel manipulators, the Delta parallel robot is one of the most popular choices in the industry due to its ability to adapt to a wide range of applications, particularly pick-and-place tasks.
Oscar Altuzarra, Mónica Urizar, Alfonso Hernández, Enrique Amezua   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Design Issues and Application of Cable-Based Parallel Manipulators for Rehabilitation Therapy

Applied Bionics and Biomechanics, 2008
In this study, cable-based manipulators are proposed for application in rehabilitation therapies. Cable-based manipulators show good features that are very useful when the system has to interact with humans.
E. Ottaviano
doaj   +1 more source

Optimum transmission performance of 3-RRR planar parallel manipulators and sensitivity analysis

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2021
In this paper, a parametric model of 3-RRR planar parallel manipulators (PPMs) is presented, aiming to optimize the overall transmission performance with optimum shapes and sizes of platforms, including the base and the mobile platform.
Kun WANG, Xiaoyong WU, Shaoping BAI
doaj   +1 more source

Stiffness analysis of overconstrained parallel manipulators [PDF]

Mechanism and Machine Theory, 2009
The paper presents a new stiffness modeling method for overconstrained parallel manipulators with flexible links and compliant actuating joints. It is based on a multidimensional lumped-parameter model that replaces the link flexibility by localized 6-dof virtual springs that describe both translational/rotational compliance and the coupling between ...
Pashkevich, Anatol, Chablat, Damien, Wenger, Philippe   +2 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-singular assembly mode changing trajectories in the workspace for the 3-RPS parallel robot [PDF]

, 2014
Having non-singular assembly modes changing trajectories for the 3-RPS parallel robot is a well-known feature. The only known solution for defining such trajectory is to encircle a cusp point in the joint space.
Chablat, Damien, Jha, Ranjan, Moroz, Guillaume, Rouillier, Fabrice   +3 more
core   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source