Results 71 to 80 of about 2,512,449 (333)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Direct kinematics of a 3-PRPS type parallel manipulator

Вестник КазНУ. Серия математика, механика, информатика, 2020
Parallel manipulators with six degrees of freedom and three limbs have a large workspace and less complex singular configurations compared to the parallel manipulators with six degrees of freedom and six limbs. This paper is presented to solve the direct
Zh. Zh. Baigunchekov, A. N. Kassinov
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Mechanism Design and Simulation Analysis of Hybrid Serial-Parallel Underwater Dredging Manipulator

水下无人系统学报
In recent years, underwater robots have emerged as a novel solution for the removal of sediments at the bottom of reservoirs, with underwater manipulators being the primary tool for dredging operations.
Yin XIA, Wenbin SU, Qiao HU, Jian ZHANG, Lin SHI   +4 more
doaj   +1 more source

Parallel Robot Translational Performance Evaluation through Direction-Selective Index (DSI)

Journal of Robotics, 2011
Performance indexes usually provide global evaluations of robot performances mixing their translational and/or rotational capabilities. This paper proposes a definition of performance index, called direction-selective index (DSI), which has been ...
G. Boschetti, R. Rosa, A. Trevisani
doaj   +1 more source

3-D Visualization on Workspace of Parallel Manipulators

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2009
In parallel mechanisms, the form and volume of workspace also change variously with the attitude of a platform. This paper presents a method to search for the workspace of parallel mechanisms with 6-DOF and 3D visualization of the workspace. Workspace is
Yoshito TANAKA, Isao YOKOMICHI, Junko ISHII, Toshiaki MAKINO   +3 more
doaj   +1 more source

Parallel Manipulators with Lower Mobility [PDF]

, 2006
Parallel manipulators with lower mobility (LM-PMs) are multi-loop mechanisms with less than six degrees of freedom (dofs). This type of manipulators has attracted the attention both of academic researchers and of industries since the early appearance of the DELTA robot (Clavel 1988). The DELTA robot showed that, when the manipulation task requires less
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dynamic Modeling and Response Analysis of an Optical Machining Robot with Prismatic Joint Clearance

Applied Sciences
The accuracy and stability of robotic systems are significantly influenced by joint clearances, especially in precision applications like optical mirror polishing.
Shuaishuai Zhu, Gang Cheng, Feng Guo, Yusong Pang   +3 more
doaj   +1 more source