Results 61 to 70 of about 5,903 (308)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Direct kinematics of a 3-PRPS type parallel manipulator
Вестник КазНУ. Серия математика, механика, информатика, 2020 Parallel manipulators with six degrees of freedom and three limbs have a large workspace and less complex singular configurations compared to the parallel manipulators with six degrees of freedom and six limbs. This paper is presented to solve the direct
Zh. Zh. Baigunchekov, A. N. Kassinov
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The kinematics of the redundant $N-1$ wire driven parallel robot [PDF]
, 2013 We address the kinematics of the redundant $N-1$ wire-driven parallel robot, i.e. a robot with $N > 3$ wires connected at the same point on the platform. The redundancy allows one to increase the workspace size.
Merlet, Jean-Pierre
core +1 more source
3-D Visualization on Workspace of Parallel Manipulators
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2009 In parallel mechanisms, the form and volume of workspace also change variously with the attitude of a platform. This paper presents a method to search for the workspace of parallel mechanisms with 6-DOF and 3D visualization of the workspace. Workspace is
Yoshito TANAKA +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Variable structure control of robot manipulators (the example of the SPRINTA) [PDF]
, 2000 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 12/01/2000.The subject of this thesis is the design and practical application of a model-based controller with variable structure control (VSC).
Nigrowsky, Pierre
core
Computer simulations of path generation and path form modification with rules working on a parallel cell-based architecture [PDF]
, 1994 Dautenhahn K, Cruse H. Computer simulations of path generation and path form modification with rules working on a parallel cell-based architecture. Computers Math. Applic.
Dautenhahn, Kerstin +3 more
core +2 more sources
Extra-Sensor Implementation in a Nonholonomic Parallel Wrist [PDF]
, 2014 The direct position analysis (DPA) of parallel manipulators (PMs) brings to determine a finite number of platform poses compatible with an assigned set of actuated-joint variables’ values. Therefore, when, during functioning, the need to check the actual
BATTISTELLI, MASSIMILIANO +2 more
core +2 more sources
Mechanism Design and Simulation Analysis of Hybrid Serial-Parallel Underwater Dredging Manipulator
水下无人系统学报In recent years, underwater robots have emerged as a novel solution for the removal of sediments at the bottom of reservoirs, with underwater manipulators being the primary tool for dredging operations.
Yin XIA +4 more
doaj +1 more source