Results 81 to 90 of about 5,903 (308)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Kinematic Characteristics of 3-UPU Parallel Manipulator in Singularity and Its Application
International Journal of Advanced Robotic Systems, 2011 This paper focuses on the kinematic characteristics of the 3‐UPU (universal‐prismatic‐ universal) parallel manipulator in one of singular configurations.
Peng Binbin, Li Zengming, Wu Kai, Sun Yu
doaj +2 more sources
Parallel Manipulators with Lower Mobility [PDF]
, 2006 Parallel manipulators with lower mobility (LM-PMs) are multi-loop mechanisms with less than six degrees of freedom (dofs). This type of manipulators has attracted the attention both of academic researchers and of industries since the early appearance of the DELTA robot (Clavel 1988). The DELTA robot showed that, when the manipulation task requires less
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Singularity analysis for six practicable 5-DoF fully-symmetrical parallel manipulators [PDF]
, 2009 Fully-symmetrical 5-DoF 3R2T parallel manipulator may be adopted in motion simulation for a spinal column. However, kinematics of these manipulators has not been studied very well because of their short history. Furthermore, the study of kinematics leads
Zhu SJ(朱思俊) +2 more
core
Dynamic Simulation for Spherical Parallel Manipulators in Grid Computing Environment
工程科学与技术, 2007 :Analytical dynamic model of 3-DOF spherical parallel manipulators is established based on sub-structure method，and a distributed parallel computing environment for dynamic simulation of spherical parallel manipulators is developed based on grid ...
doaj
Jixie chuandong, 2008 At singularities, the parallel manipulator will have more than one the motion trends. So the parallel manipulator will lose control. Based on the bifurcation characteristics of a parallel manipulator at singularities, a new method to estimate the losing ...
郭瑞琴
doaj
Depth-Dependent Control in Vision-Sensor Space for Reconfigurable Parallel Manipulators. [PDF]
Sensors (Basel), 2023 Franco-López A +4 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source