Results 61 to 70 of about 33,400 (300)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Parallel Robot Translational Performance Evaluation through Direction-Selective Index (DSI)

Journal of Robotics, 2011
Performance indexes usually provide global evaluations of robot performances mixing their translational and/or rotational capabilities. This paper proposes a definition of performance index, called direction-selective index (DSI), which has been ...
G. Boschetti, R. Rosa, A. Trevisani
doaj   +1 more source

Direct kinematics of a 3-PRPS type parallel manipulator

Вестник КазНУ. Серия математика, механика, информатика, 2020
Parallel manipulators with six degrees of freedom and three limbs have a large workspace and less complex singular configurations compared to the parallel manipulators with six degrees of freedom and six limbs. This paper is presented to solve the direct
Zh. Zh. Baigunchekov, A. N. Kassinov
doaj   +1 more source

A study of the singularity locus in the joint space of planar parallel manipulators: special focus on cusps and nodes [PDF]

, 2011
Cusps and nodes on plane sections of the singularity locus in the joint space of parallel manipulators play an important role in nonsingular assembly-mode changing motions.
Chablat, Damien, Wenger, Philippe, Zaiter, Abdel Kader   +2 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Moveability and Collision Analysis for Fully-Parallel Manipulators [PDF]

, 1998
International audienceThe aim of this paper is to characterize the moveability of fully-parallel manipulators in the presence of obstacles. Fully parallel manipulators are used in applications where accuracy, stiffness or high speeds and accelerations ...
Chablat, Damien, Wenger, Philippe
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Mechanism Design and Simulation Analysis of Hybrid Serial-Parallel Underwater Dredging Manipulator

水下无人系统学报
In recent years, underwater robots have emerged as a novel solution for the removal of sediments at the bottom of reservoirs, with underwater manipulators being the primary tool for dredging operations.
Yin XIA, Wenbin SU, Qiao HU, Jian ZHANG, Lin SHI   +4 more
doaj   +1 more source

3-D Visualization on Workspace of Parallel Manipulators

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2009
In parallel mechanisms, the form and volume of workspace also change variously with the attitude of a platform. This paper presents a method to search for the workspace of parallel mechanisms with 6-DOF and 3D visualization of the workspace. Workspace is
Yoshito TANAKA, Isao YOKOMICHI, Junko ISHII, Toshiaki MAKINO   +3 more
doaj   +1 more source

Parallel Manipulators with Lower Mobility [PDF]

, 2006
Parallel manipulators with lower mobility (LM-PMs) are multi-loop mechanisms with less than six degrees of freedom (dofs). This type of manipulators has attracted the attention both of academic researchers and of industries since the early appearance of the DELTA robot (Clavel 1988). The DELTA robot showed that, when the manipulation task requires less
openaire   +3 more sources