Results 11 to 20 of about 1,793 (174)

Biocatalytic Detoxification of Paralytic Shellfish Toxins. [PDF]

ACS Chem Biol, 2019
Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatment of numerous neurodegenerative diseases and pain. Nature is a highly skilled medicinal chemist in this regard, designing potent VGSC ligands capable of binding to and blocking the channel, thereby offering compounds of potential therapeutic interest ...
Lukowski AL, Denomme N, Hinze ME, Hall S, Isom LL, Narayan ARH.   +5 more
europepmc   +4 more sources

A Sub-Acute Dosing Study of Saxitoxin and Tetrodotoxin Mixtures in Mice Suggests That the Current Paralytic Shellfish Toxin Regulatory Limit Is Fit for Purpose

Toxins, 2023
Paralytic shellfish poisoning is a worldwide problem induced by shellfish contaminated with paralytic shellfish toxins. To protect human health, a regulatory limit for these toxins in shellfish flesh has been adopted by many countries. In a recent study,
Sarah C. Finch, Nicola G. Webb, Michael J. Boundy, D. Tim Harwood, John S. Munday, Jan M. Sprosen, Chanatda Somchit, Ric B. Broadhurst   +7 more
doaj   +1 more source

Marine Biotoxins in Whole and Processed Scallops from the Argentine Sea

Marine Drugs, 2022
Harmful algal blooms are an increasing worldwide threat to the seafood industry and human health as a consequence of the natural production of biotoxins that can accumulate in shellfish.
Alejandra B. Goya, Danial Baqer, Ryan P. Alexander, Patrycja Stubbs, Karl Dean, Adam M. Lewis, Lewis Coates, Benjamin H. Maskrey, Andrew D. Turner   +8 more
doaj   +1 more source

A Year of Bio-Monitoring (2021): Presence of Algae of the Genus Alexandrium, Dinophysis, Prorocentrum and Non-Compliance for Paralytic Toxins and Lipophilic Toxins in Bivalve Mollusks Bred in Sardinia (W Mediterranean Sea)

Journal of Marine Science and Engineering, 2022
Bivalve mollusk production represents the principal aquaculture activity in Sardinia (40°03′ N, 9°05′ E). In 2021, 859 water samples and 1270 mollusk samples were analyzed.
Giuseppa Lorenzoni, Anna Maria Bazzoni, Monica Cangini, Sonia Dall’Ara, Rita Melillo, Alessandro Graziano Mudadu, Simona Cau, Barbara Soro, Salvatore Ledda, Gabriella Piras, Tiziana Tedde, Sara Salza, Igor Arras, Giuseppa Porqueddu, Domenico Meloni   +14 more
doaj   +1 more source

Immunoassay Methods for Paralytic Shellfish Poisoning Toxins [PDF]

Journal of AOAC INTERNATIONAL, 2001
Abstract The current status of immunochemical techniques for analysis of paralytic shellfish poisoning (PSP) toxins is summarized. Important aspects regarding production of the biological reagents necessary for immunochemical methods, the characteristics of polyclonal and monoclonal antibodies against saxitoxin and neosaxitoxin, and the ...
E, Usleber, R, Dietrich, C, Bürk, E, Schneider, E, Märtlbauer   +4 more
openaire   +2 more sources

Shellfish Toxin Uptake and Depuration in Multiple Atlantic Canadian Molluscan Species: Application to Selection of Sentinel Species in Monitoring Programs

Toxins, 2021
Shellfish toxin monitoring programs often use mussels as the sentinel species to represent risk in other bivalve shellfish species. Studies have examined accumulation and depuration rates in various species, but little information is available to compare
Wade A. Rourke, Andrew Justason, Jennifer L. Martin, Cory J. Murphy   +3 more
doaj   +1 more source

Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase [PDF]

ACS Chemical Biology, 2020
Secondary metabolites are assembled by enzymes that often perform reactions with high selectivity and specificity. Many of these enzymes also tolerate variations in substrate structure, exhibiting promiscuity that enables various applications of a given biocatalyst.
April L. Lukowski, Leena Mallik, Meagan E. Hinze, Brian M. Carlson, Duncan C. Ellinwood, Joshua B. Pyser, Markos Koutmos, Alison R. H. Narayan   +7 more
openaire   +2 more sources

Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review

Toxins, 2022
Phytoplankton are photosynthetic microorganisms in aquatic environments that produce many bioactive substances. However, some of them are toxic to aquatic organisms via filter-feeding and are even poisonous to humans through the food chain.
Biswajita Pradhan, Hansol Kim, Sofia Abassi, Jang-Seu Ki   +3 more
doaj   +1 more source

Human shellfish poisoning: Implementation of a national surveillance program in France

Frontiers in Marine Science, 2023
Toxic algae and their toxins represent an emerging public health issue, particularly due to global warming. The toxicological mechanisms of neurotoxic phycotoxins and their human health effects have been widely described (paralytic, neurological, amnesic,
Sandra Sinno-Tellier, Eric Abadie, Sophie Guillotin, Anne Bossée, Marina Nicolas, Nicolas Delcourt, Nicolas Delcourt   +6 more
doaj   +1 more source

Occurrence of harmful algal species and shellfish toxicity in Sardinia (Italy)

Italian Journal of Food Safety, 2016
Sardinia (Italy, north-western Mediterranean) is a commercially important producer of edible bivalve molluscs. Since the early 2000s, it was subjected to recurring cases of mussel farm closures due to toxic algal poison.
Anna Maria Bazzoni, Alessandro Graziano Mudadu, Giuseppa Lorenzoni, Igor Arras, Antonella Lugliè, Barbara Vivaldi, Valentina Cicotelli, Giovanna Sanna, Giuseppe Tedde, Salvatore Ledda, Enrico Alesso, Edoardo Marongiu, Sebastiano Virgilio   +12 more
doaj   +1 more source