Results 1 to 10 of about 23,241 (140)

Paramyxoviruses in Old World fruit bats (Pteropodidae): An open database and synthesis of sampling effort, viral positivity, and coevolution. [PDF]

PLoS Neglected Tropical Diseases
Over the past 30 years, research interest in the links between Old World fruit bats (family Pteropodidae) and paramyxoviruses has driven a rapid proliferation of surveillance studies in this system.
Maya M Juman, Olivier Restif, Daniel J Becker   +2 more
doaj   +2 more sources

Evidence that hPIV2 paramyxovirus antigenomes are edited during infection [PDF]

mBio
Mononegavirus genomes contain cis-acting sequences that direct the formation of mRNA 5′ and 3′ ends during synthesis (gene start [GS] and gene end [GE]) but are silent during antigenome synthesis from the same genome template.
Keisuke Ohta, Junna Kawasaki, Daniel Kolakofsky, Machiko Nishio, Yusuke Matsumoto   +4 more
doaj   +2 more sources

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]

, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
A Komuro, A Peisley, A Pichlmair, A Pichlmair, AM Bruns, D Bamming, DA Pippig, DE Levy, DW Leung, G Lennon, H Kato, H Kato, IC Berke, IC Berke, J Andrejeva, K Childs, K Childs, Karen L. Mossman, Kay S. Childs, KS Childs, L Didcock, L Strahle, M Binder, M Schlee, M Yoneyama, MD Johnston, MJ Killip, N Masson, P King, R Marais, R Randall, Richard E. Randall, S Goodbourn, S Rothenfusser, Stephen Goodbourn, T Satoh, T Venkataraman, V Hornung, X Li, Y Kumagai, YM Loo, YM Loo   +41 more
core   +19 more sources

Seroprevalence of Infection with Feline Morbilliviruses Is Associated with FLUTD and Increased Blood Creatinine Concentrations in Domestic Cats

Viruses, 2021
Feline morbilliviruses (FeMV) are fairly newly discovered paramyxoviruses found in cats. The first description indicated an association with widely distributed chronic kidney disease (CKD) in the host species.
Johannes Busch, Romy M. Heilmann, Thomas W. Vahlenkamp, Michael Sieg   +3 more
doaj   +1 more source

Human Paramyxovirus Infections Induce T Cells That Cross-React with Zoonotic Henipaviruses

mBio, 2020
Humans are infected with paramyxoviruses of different genera early in life, which induce cytotoxic T cells that may recognize conserved epitopes. This raises the question of whether cross-reactive T cells induced by antecedent paramyxovirus infections ...
Rory D. de Vries, Alwin de Jong, R. Joyce Verburgh, Lucie Sauerhering, Gijsbert P. van Nierop, Robert S. van Binnendijk, Albert D. M. E. Osterhaus, Andrea Maisner, Marion P. G. Koopmans, Rik L. de Swart   +9 more
doaj   +1 more source

Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5. [PDF]

, 2020
During the replication of parainfluenza virus 5 (PIV5), copyback defective virus genomes (DVGs) are erroneously produced and are packaged into "infectious" virus particles.
Goodbourn, S, Hughes, DJ, Randall, RE, Short, JAL, Vasou, A, Wignall-Fleming, EB, Young, D   +6 more
core   +3 more sources

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. [PDF]

, 2015
Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion.
Aguilar, Hector C, Akyol-Ataman, Zeynep, Bradel-Tretheway, Birgit, Broder, Christopher C, Chan, Yee-Peng, Dutta, Somnath, Feng, YanRu, Lee, Benhur, Nikolov, Dimitar B, Skiniotis, Georgios, Wang, Lin-Fa, Xu, Kai, Yan, Lianying, Zhou, Z Hong, Zhu, Yongqun   +14 more
core   +6 more sources

Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation

mBio, 2022
Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals.
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose   +8 more
doaj   +1 more source

Achimota Pararubulavirus 3: A New Bat-Derived Paramyxovirus of the Genus Pararubulavirus

Viruses, 2020
Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic.
Kate S. Baker, Mary Tachedjian, Jennifer Barr, Glenn A. Marsh, Shawn Todd, Gary Crameri, Sandra Crameri, Ina Smith, Clare E.G. Holmes, Richard Suu-Ire, Andres Fernandez-Loras, Andrew A. Cunningham, James L.N. Wood, Lin-Fa Wang   +13 more
doaj   +1 more source

Nipah Virus Efficiently Replicates in Human Smooth Muscle Cells without Cytopathic Effect

Cells, 2021
Nipah virus (NiV) is a highly pathogenic zoonotic virus with a broad species tropism, originating in pteropid bats. Human outbreaks of NiV disease occur almost annually, often with high case-fatality rates.
Blair L. DeBuysscher, Dana P. Scott, Rebecca Rosenke, Victoria Wahl, Heinz Feldmann, Joseph Prescott   +5 more
doaj   +1 more source